Evidence map›Paper›PMID 40797035›Full record

ArticleScientific reports2025

Role of prokineticins and T-reg cells in obesity-associated metabolic oxidative dysregulation in NAFLD.

Shyam Prakash, Priyatma, Ram Aasarey, Shahid Khan, Naval K Vikram, Shalimar, Medha, Saumya Srivastava, Shivam Pandey, Akanksha Priya and 1 more

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shyam PrakashDepartment of Laboratory Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India. prakashaiims@gmail.com.
PriyatmaDepartment of Laboratory Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
Ram AasareyDepartment of Laboratory Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
Shahid KhanDepartment of Laboratory Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
Naval K VikramDepartment of Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
ShalimarDepartment of Gastroenterology & Human Nutrition, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
MedhaDepartment of Laboratory Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
Saumya SrivastavaDepartment of Laboratory Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
Shivam PandeyDepartment of Biostatistics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
Akanksha PriyaDepartment of Laboratory Medicine, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
Sandeep AggarwalDepartment of Surgical Disciplines, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.

Funding

Indian Council of Medical Research project code: 5/9/1330/2020_Nut
6 · The paper itself

Abstract

We investigate the role of prokineticin, T-reg cells, and oxidative metabolism in the progression of obesity-related NASH to HCC. Our findings on a cohort of 250 patients, including Obese NAFLD and Non-Obese NAFLD, reveal significant insights. In Obese NAFLD, PK-1 mRNA expression was reduced by 2.4-fold (p < 0.01) compared to Non-Obese NAFLD, while PK-2 was upregulated by 1.4-fold (p < 0.005), and FABP-5 increased by 1.4-fold (p < 0.005) compared to T2DM. IL-10 mRNA expression was 2.4-fold higher (p < 0.005) in MetS verses to Non-Obese NAFLD. Nrf-2 expression was elevated by 1.13-fold in Non-Obese NAFLD compared to Obese NAFLD (p < 0.05). Flow cytometric analysis of T-reg cells was three times lower in Obese NAFLD compared to MetS (p < 0.005), with a notable reduction in CD8

Indexed as

Gastrointestinal HormonesNon-alcoholic Fatty Liver DiseaseObesityVascular Endothelial Growth Factor, Endocrine-Gland-DerivedAdultCarcinoma, HepatocellularFemaleHumansInterleukin-10Liver NeoplasmsMaleMiddle AgedNeuropeptidesOxidative StressGastrointestinal HormonesInterleukin-10NeuropeptidesPROK2 protein, humanVascular Endothelial Growth Factor, Endocrine-Gland-Derived

Identifiers

PMID40797035
PMCPMC12344004

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.