ArticleJournal of perinatology : official journal of the California Perinatal Association2025
Gestational age-based outcomes of neonates with Down syndrome in the neonatal intensive care unit (NICU): review of pediatric health information system (PHIS) database.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Down Syndrome Births Among Live Births from the CDC Wonder Database.Children (Basel, Switzerland) · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine differences in neonatal intensive care unit (NICU) outcomes in neonates with Down syndrome (DS) by gestational age (GA) using a large national database STUDY
designRetrospective analysis of Pediatric Health Information System database, including neonates with DS admitted to the NICU <30 days old from 1/1/2008-12/31/2022. Neonates were stratified by GA (extremely preterm, very preterm, moderate/late preterm, term). GA-based risk differences were examined for NICU outcomes using term neonates as reference.
resultsOverall mortality rate was 7% with increasing mortality as GA decreased (RD 6.1 [95% CI 4.8, 7.5], RD 25.4 [95% CI 20.5, 30.6], RD 36.8 [95% CI 27.3, 46.8] for moderate/late preterm, very preterm, extremely preterm). The overall rate of pulmonary hypertension was 23% and 14% of the cohort required a gastrostomy tube.
conclusionPrematurity significantly increases risk of NICU mortality for neonates with DS. Rates of pulmonary hypertension and gastrostomy were high throughout all groups.
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