ArticleJournal of neurology2025
Early-life and adult body mass index in relation to MS disability progression.
Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Genetic modification of obesity-associated disability progression in multiple sclerosis.Journal of neurology · 2026Article
- Artificial Intelligence-Based Muscle Ultrasound: A Novel Approach to Nutritional Evaluation Beyond Quantity in Neurological Patients.Nutrients · 2026Observational
- Is Obesity a Modifiable Risk Factor in Multiple Sclerosis? Mechanistic Insights into Neuroinflammation and Oxidative Damage.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
BACKGROUND AND
objectivesThe influence of body weight across the life course on multiple sclerosis (MS) progression remains incompletely understood. While excess body mass at diagnosis is associated with disability progression, it is unclear how early-life and adult BMI jointly affect long-term outcomes. We aimed to investigate the separate and combined effects of BMI at age 20 and at diagnosis on MS progression.
methodsWe studied 2940 individuals with relapsing-onset MS from a population-based case-control study with prospective follow-up through the Swedish MS registry. BMI was calculated from self-reported weight at age 20 and at diagnosis. Outcomes included confirmed disability worsening (CDW), and time to reach EDSS 3 and EDSS 4. Cox regression and general linear models were used to examine associations between BMI and MS progression, including interaction terms.
resultsHigh BMI (> 28 kg/m
conclusionsHigh BMI at diagnosis was associated with faster disability progression, particularly when present since early adulthood. These findings underscore the potential benefits of early weight management in MS.
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