Evidence map›Paper›PMID 40796926›Full record

Trial reportScientific reports2025

Comparison of microcurrent and low level laser therapy on matrix metalloproteinases and tissue inhibitors of metalloproteinases expressions in surgical wound healing.

Ayman Mohammed El Makakey, Mohammed H Hassan, Nehad A Abo-Zaid, Bakheet E M Elsadek, Mahmoud A Hifny, Radwa Mahmoud Elsharaby, Mohammed E Ali

Abstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ayman Mohammed El MakakeyDepartment of Physical Therapy for Surgery, Faculty of Physical Therapy, Benha University, Benha, Egypt.
Mohammed H HassanDepartment of Medical Biochemistry, Faculty of Medicine, South Valley University, Qena, 83523, Egypt. mohammedhosnyhassaan@med.svu.edu.eg.ORCID http://orcid.org/0000-0003-2698-9438
Nehad A Abo-ZaidDepartment of Physical Therapy for Pediatrics, Faculty of Physical Therapy, South Valley University, Qena, 83523, Egypt.
Bakheet E M ElsadekDepartment of Biochemistry and Molecular Biology, Faculty of Pharmacy, Assiut Branch, Al-Azhar University, Assiut, 71524, Egypt.
Mahmoud A HifnyDepartment of Plastic Surgery, Faculty of Medicine, South Valley University, Qena, 83523, Egypt.
Radwa Mahmoud ElsharabyDepartment Clinical Pathology, Faculty of Medicine, Tanta University, Tanta, Egypt.
Mohammed E AliDepartment of Physical Therapy for Surgery , Faculty of Physical Therapy, South Valley University, Qena, 83523, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe purpose of this study was to compare the modulation effects of Microcurrent Therapy (MT) and Low-Level Laser Therapy (LLLT) on Matrix Metalloproteinases (MMPs) and tissue inhibitors of Metalloproteinases (TIMPs) expressions during healing of surgical wounds using appendectomy wound as a model.

methodsNinety patients who recently underwent appendectomy were randomly divided into 3 main groups of equal numbers. All cases in the three groups received ordinary medical therapy. Moreover, group A (MT group) received Microcurrent Therapy for 20 min. In addition to a designed physical therapy treatment protocol for 20 min. Group B (LLLT group) received Low-Level Laser Therapy for 20 min., plus the same designed physical therapy treatment protocol for 20 min. Group C (placebo group) received placebo shame LLLT for 20 min. plus the same designed physical therapy treatment protocol for 20 min. Enzyme-linked immunosorbent assay (ELISA) and Western Blot Technique (WBT) were used to determine expression levels of MMP-8, MMP-9, and TIMP-1 at the beginning of treatment and after the end of twelve successive sessions.

resultsFollowing therapies, results showed a statistically significant decrease in the MMP-8 and MMP-9 expressions with significantly increased expression levels of TIMP-1 in each group separately (P < 0.05). These changes in the expression levels towards proper healing of surgical wounds were more obvious in MT and LLLT groups compared to the placebo group, with significantly better effect in the LLLT group compared to the MT group .

conclusionMicrocurrent therapy and low-level laser therapy have a notable impact in improving wound healing process as they can significantly affect the expression levels of matrix metalloproteinases and tissue inhibitors of metalloproteinases towards good prognosis of healing process and decreasing possible wound healing complication, with superior effect of low-level laser therapy.

Indexed as

Low-Level Light TherapyMatrix Metalloproteinase 8Matrix Metalloproteinase 9Surgical WoundTissue Inhibitor of Metalloproteinase-1Wound HealingAdultFemaleHumansMaleMiddle AgedYoung AdultMatrix Metalloproteinase 8Matrix Metalloproteinase 9Tissue Inhibitor of Metalloproteinase-1Clinical trialLow level laser therapyMatrix metalloproteinases and the tissue inhibitors of metalloproteinasesMicrocurrent therapyWound healing

Identifiers

PMID40796926
PMCPMC12343887

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.