Evidence map›Paper›PMID 40796874›Full record

ArticleJournal of ovarian research2025

Smooth endoplasmic reticulum aggregates in oocytes: a comparison of progestin-primed and GnRH antagonist IVF protocols.

Hsien-Ming Wu, Cindy Hsuan Weng, Yen-Ju Sung, Le-Tien Hsu, Shang-Yu Huang, Chia-Lin Chang, Hong-Yuan Huang, Yung-Kuei Soong, Liang-Hsuan Chen

Abstract readComparative Study
PubMed Full text at PMC Publisher
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Article in Journal of ovarian research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Hsien-Ming WuDepartment of Obstetrics and Gynecology, LinKou Medical Center, Chang Gung Memorial Hospital, No. 5, Fusing St., Gueishan Dist, Taoyuan City, 333, Taiwan.
Cindy Hsuan WengDepartment of Obstetrics and Gynecology, LinKou Medical Center, Chang Gung Memorial Hospital, No. 5, Fusing St., Gueishan Dist, Taoyuan City, 333, Taiwan.
Yen-Ju SungDepartment of Obstetrics and Gynecology, LinKou Medical Center, Chang Gung Memorial Hospital, No. 5, Fusing St., Gueishan Dist, Taoyuan City, 333, Taiwan.
Le-Tien HsuDepartment of Obstetrics and Gynecology, LinKou Medical Center, Chang Gung Memorial Hospital, No. 5, Fusing St., Gueishan Dist, Taoyuan City, 333, Taiwan.
Shang-Yu HuangDepartment of Obstetrics and Gynecology, LinKou Medical Center, Chang Gung Memorial Hospital, No. 5, Fusing St., Gueishan Dist, Taoyuan City, 333, Taiwan.
Chia-Lin ChangDepartment of Obstetrics and Gynecology, LinKou Medical Center, Chang Gung Memorial Hospital, No. 5, Fusing St., Gueishan Dist, Taoyuan City, 333, Taiwan.
Hong-Yuan HuangDepartment of Obstetrics and Gynecology, LinKou Medical Center, Chang Gung Memorial Hospital, No. 5, Fusing St., Gueishan Dist, Taoyuan City, 333, Taiwan.
Yung-Kuei SoongDepartment of Obstetrics and Gynecology, LinKou Medical Center, Chang Gung Memorial Hospital, No. 5, Fusing St., Gueishan Dist, Taoyuan City, 333, Taiwan.
Liang-Hsuan ChenDepartment of Obstetrics and Gynecology, LinKou Medical Center, Chang Gung Memorial Hospital, No. 5, Fusing St., Gueishan Dist, Taoyuan City, 333, Taiwan. elsachen0119@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVitrification improves post-thawed embryo recovery and enables new strategies for in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI). Due to its convenience and efficacy, progestin-primed ovarian stimulation (PPOS) gets more attention in daily practice. However, concerns about the impact of PPOS on oocyte and embryo quality still exist. We aimed to compare the embryological and pregnancy outcomes between PPOS and gonadotropin-releasing hormone (GnRH) antagonist protocol in IVF/ICSI cases.

methodsThis was a retrospective cohort study of 545 women undergoing IVF/ICSI cycles from July 2017 to December 2018. The patients were allocated into two groups: the PPOS and GnRH antagonist group, based on 1:1 propensity score matching. In both groups, all viable embryos were cryopreserved for later transfer. The primary endpoint was the prevalence of smooth endoplasmic reticulum aggregates (SERa) in oocytes. Secondary outcomes included the cycle characteristics and pregnancy outcomes.

resultsOvarian stimulation duration and serum estradiol level on trigger day were significantly higher in the PPOS group compared to the GnRH antagonist group. The prevalence of SERa + cycles was 9.4% in our cohort (13.0% and 12.2% in the PPOS and GnRH antagonist groups, respectively, p = 0.221). There were more frozen embryos (5.3 ± 4.5 vs. 4.8 ± 4.0, p = 0.378) in the PPOS group than in the GnRH group, particularly for the subgroup of low responders (1.6 ± 1.2 vs. 1.2 ± 1.0, p = 0.043). No significant differences were observed between the groups regarding clinical pregnancy rate, miscarriage, live birth rate, and cumulative live birth rate in the following two years after oocyte retrieval.

conclusionsOur findings suggest that the PPOS protocol provides clinical benefits and safety with comparable oocyte quality and pregnancy outcomes to the GnRH antagonist protocol.

Indexed as

Endoplasmic Reticulum, SmoothFertilization in VitroGonadotropin-Releasing HormoneOocytesOvulation InductionProgestinsAdultCryopreservationFemaleHormone AntagonistsHumansPregnancyPregnancy OutcomePregnancy RateRetrospective StudiesSperm Injections, IntracytoplasmicGonadotropin-Releasing HormoneHormone AntagonistsProgestinsCumulative live birthGonadotropin-releasing hormone antagonistIn vitro fertilizationProgestin-primed ovarian stimulationSmooth endoplasmic reticulum aggregates

Identifiers

PMID40796874
PMCPMC12341073

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.