Evidence map›Paper›PMID 40796752›Full record

ArticleNature communications2025

Mapping the coupling between tract reachability and cortical geometry of the human brain.

Deying Li, Andrew Zalesky, Yufan Wang, Haiyan Wang, Liang Ma, Luqi Cheng, Tobias Banaschewski, Gareth J Barker, Arun L W Bokde, Rüdiger Brühl and 22 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

32 authors.

Deying LiBeijing Key Laboratory of Brainnetome and Brain-Computer Interface, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
Andrew ZaleskySystems Lab, Department of Psychiatry, The University of Melbourne, Victoria, VIC, Australia.ORCID http://orcid.org/0000-0003-2298-9908
Yufan WangBeijing Key Laboratory of Brainnetome and Brain-Computer Interface, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
Haiyan WangBeijing Key Laboratory of Brainnetome and Brain-Computer Interface, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
Liang MaBeijing Key Laboratory of Brainnetome and Brain-Computer Interface, Institute of Automation, Chinese Academy of Sciences, Beijing, China.
Luqi ChengSchool of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin, China.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, German Center for Mental Health (DZPG), Mannheim, Germany.ORCID http://orcid.org/0000-0003-4595-1144
Gareth J BarkerDepartment of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-5214-7421
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0003-0114-4914
Rüdiger BrühlPhysikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0003-0111-5996
Sylvane DesrivièresSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0002-9120-7060
Herta FlorInstitute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.ORCID http://orcid.org/0000-0003-4809-5398
Hugh GaravanDepartments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.ORCID http://orcid.org/0000-0002-8939-1014
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham, University Park, Nottingham, UK.ORCID http://orcid.org/0000-0002-4900-4817
Antoine GrigisNeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
Andreas HeinzDepartment of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.ORCID http://orcid.org/0000-0001-5405-9065
Hervé LemaîtreNeuroSpin, CEA, Université Paris-Saclay, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0002-5952-076X
Jean-Luc MartinotInstitut National de la Santé et de la Recherce Médicale, INSERM U1299 "Trajectoires développementales & psychiatrie", University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay; Centre Borelli CNRS 9010, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0002-0136-0388
Marie-Laure Paillère MartinotInstitut National de la Santé et de la Recherce Médicale, INSERM U1299 "Trajectoires développementales & psychiatrie", University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay; Centre Borelli CNRS 9010, Gif-sur-Yvette, France.
Eric ArtigesInstitut National de la Santé et de la Recherce Médicale, INSERM U1299 "Trajectoires développementales & psychiatrie", University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay; Centre Borelli CNRS 9010, Gif-sur-Yvette, France.ORCID http://orcid.org/0000-0003-4461-7646
Frauke NeesDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, German Center for Mental Health (DZPG), Mannheim, Germany.ORCID http://orcid.org/0000-0002-7796-8234
Dimitri Papadopoulos OrfanosDepartment of Psychology, School of Social Sciences, University of Mannheim, Mannheim, Germany.ORCID http://orcid.org/0000-0002-1242-8990
Luise PoustkaDepartment of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, University Hospital Heidelberg, Heidelberg, Germany.
Michael N SmolkaDepartment of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0001-5398-5569
Nilakshi VaidyaCentre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Burlington, Germany.ORCID http://orcid.org/0000-0002-4600-7158
Henrik WalterDepartment of Psychiatry and Psychotherapy CCM, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin and Berlin Institute of Health, Berlin, Germany.ORCID http://orcid.org/0000-0002-9403-6121
Robert WhelanSchool of Psychology and Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland.ORCID http://orcid.org/0000-0002-2790-7281
Gunter SchumannDepartment of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany.ORCID http://orcid.org/0000-0002-7740-6469
Tianye JiaCentre for Population Neuroscience and Precision Medicine (PONS), Institute for Science and Technology of Brain-inspired Intelligence (ISTBI), Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0001-5399-2953
Congying ChuBeijing Key Laboratory of Brainnetome and Brain-Computer Interface, Institute of Automation, Chinese Academy of Sciences, Beijing, China. congying.chu@ia.ac.cn.ORCID http://orcid.org/0000-0002-7808-8896
Lingzhong FanBeijing Key Laboratory of Brainnetome and Brain-Computer Interface, Institute of Automation, Chinese Academy of Sciences, Beijing, China. lingzhong.fan@ia.ac.cn.ORCID http://orcid.org/0000-0002-4813-621X
IMAGEN Consortium

Funding

Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
A decentralized macro and micro gene-by-environment interaction analysis of substance use behavior and its brain biomarkers R01DA049238 · NIDA · GEORGIA STATE UNIVERSITY · PI CALHOUN, VINCE D, LIU, JINGYU · 2019 to 2023
$2.9M
ENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683k
NIA NIH HHS R56 AG058854NIBIB NIH HHS U54 EB020403NIDA NIH HHS R01 DA049238NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

The study of cortical geometry and connectivity is prevalent in human brain research. However, these two aspects of brain structure are usually examined separately, leaving the essential connections between the brain's folding patterns and white matter connectivity unexplored. In this study, we aim to elucidate the fundamental links between cortical geometry and white matter tract connectivity. We develop the concept of tract-geometry coupling (TGC) by optimizing the alignment between tract connectivity to the cortex and multiscale cortical geometry. We confirm in two independent datasets that cortical geometry reliably characterizes tract reachability, and that TGC demonstrates high test-retest reliability and individual-specificity. Interestingly, low-frequency TGC is more heritable and behaviorally informative. Finally, we find that TGC can reproduce task-evoked cortical activation patterns and exhibits non-uniform maturation during youth. Collectively, our study provides an approach to mapping cortical geometry-connectivity coupling, highlighting how these two aspects jointly shape the connected brain.

Indexed as

BrainBrain MappingCerebral CortexWhite MatterAdolescentAdultDiffusion Tensor ImagingFemaleHumansMagnetic Resonance ImagingMaleNeural PathwaysReproducibility of ResultsYoung Adult

Identifiers

PMID40796752
PMCPMC12343958

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.