Evidence map›Paper›PMID 40796676›Full record

ArticleNPJ precision oncology2025

Genome-wide cfDNA fragmentation patterns in cerebrospinal fluid reflect medulloblastoma groups.

Alexander L Markowitz, Chetan Munugula, Eirini Christodoulou, Jianling Ji, Liya Xu, Jennifer A Cotter, Venkata Yellapantula

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ precision oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alexander L MarkowitzDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Chetan MunugulaDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Eirini ChristodoulouDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Jianling JiDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Liya XuThe Vision Center, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Jennifer A CotterDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Venkata YellapantulaDepartment of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA. vyellapantula@chla.usc.edu.

Funding

Childhood Eye Cancer Trust 8031000-000015582Children's Hospital Los Angeles Translational Research Fund 8231000-TUA010247
6 · The paper itself

Abstract

Identifying molecular groups in medulloblastoma currently requires invasive biopsies for accurate diagnosis. We analyzed cerebrospinal fluid cell-free DNA (cfDNA) fragmentation patterns in 122 samples as a minimally-invasive alternative. Our analysis confirmed established group-specific copy number alterations and identified distinct fragmentation patterns for each group. Our integrated meta-classifier achieved high accuracy (mean-AUC 0.94) in distinguishing the four molecular groups, demonstrating cfDNA fragmentomics' potential for improving diagnosis and personalized treatment strategies.

Identifiers

PMID40796676
PMCPMC12343951

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.