Embryonic motor neuron programming factors reactivate immature gene expression and suppress ALS pathologies in postnatal motor neurons.
Emily R Lowry, Tulsi Patel, Jonathon A Costa, Elizabeth Chang, Shahroz Tariq, Hranush Melikyan, Ian Davis, Siaresh Aziz, Georgia Ntermentzaki, Francesco Lotti and 1 more
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Emily R Lowry *Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA. el2139@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-8412-3168
Siaresh AzizDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
Georgia NtermentzakiDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Francesco LottiDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Hynek WichterleDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA. hw350@cumc.columbia.edu.ORCID http://orcid.org/0000-0002-7817-0080
Funding
Distal enhancers controlling motor neuron gene expression programR01NS109217 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WICHTERLE, HYNEK · 2019 to 2022
$2.1M
Transcriptional Control of Motor Neuron MaturationR01NS116141 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WICHTERLE, HYNEK · 2020 to 2024
$1.9M
Effects of Re-expression of Motor Neuron Selector Transcription Factors on ALS PathologyR01NS140764 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Hynek Wichterle · 2025 to 2026
$1.3M
Defining motor neuron diversity from embryo to adulthood and generating tools for in vivo and in vitro accessK99NS121136 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI PATEL, TULSI · 2021 to 2022
$272k
NINDS NIH HHS K99 NS121136NINDS NIH HHS R01 NS109217NINDS NIH HHS R01 NS116141NINDS NIH HHS R01 NS140764U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) K99NS121136U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS109217U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS116141U.S. Department of Health & Human Services | NIH | National Institute of Neurological Disorders and Stroke (NINDS) R01NS140764
6 · The paper itself
Abstract
Aging is a major risk factor in amyotrophic lateral sclerosis (ALS) and other adult-onset neurodegenerative disorders. Whereas young neurons are capable of buffering disease-causing stresses, mature neurons lose this ability and degenerate over time. We hypothesized that the resilience of young motor neurons could be restored by reexpression of the embryonic motor neuron selector transcription factors ISL1 and LHX3. We found that viral reexpression of ISL1 and LHX3 selectively in postnatal motor neurons reactivates aspects of their youthful gene expression program and alleviates key disease-relevant phenotypes in the SOD1
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Embryonic motor neuron programming factors reactivate immature gene expression and suppress ALS pathologies in postnatal motor neurons. · full record | OpenQuestion