Evidence map›Paper›PMID 40796662›Full record

ArticleNature immunology2025

A STUB1-CHIC2 complex inhibits CD8

Martin W LaFleur, Lauren E Milling, Priyamvada Prathima, Vivian Li, Ashlyn M Lemmen, Ivy S L Streeter, Paul K S Heisig, Nicole M Derosia, Elizabeth Riffo, Haonan Xu and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. AbioRxiv : the preprint server for biology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Martin W LaFleur *Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. martin_lafleur@hms.harvard.edu.ORCID http://orcid.org/0000-0002-5017-774X
Lauren E Milling *Department of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0009-0002-4604-9435
Priyamvada PrathimaDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Vivian LiDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Ashlyn M LemmenDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Ivy S L StreeterDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-0729-1042
Paul K S HeisigDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Nicole M DerosiaDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Elizabeth RiffoDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Haonan XuDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Thao H NguyenDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2767-0528
Aashiya KolengadenDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Samuel C MarksonDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9053-9867
John G DoenchBroad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0002-3707-9889
Arlene H SharpeDepartment of Immunology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA. arlene_sharpe@hms.harvard.edu.ORCID http://orcid.org/0000-0002-9736-2109

Funding

Role of Negative Costimulation in Regulation of AutoimmunityP01AI039671 · NIAID · YALE UNIVERSITY · PI David A. Hafler · 1996 to 2026
$51.7M
Synergies among inhibitory receptors in tolerance, cancer & antiviral immunityP01AI108545 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI E. John Wherry · 2015 to 2026
$30.8M
Project 2: Genes required for dendritic cell responses to pathogens and T cellsU19AI133524 · NIAID · HARVARD MEDICAL SCHOOL · PI SHARPE, ARLENE H. · 2017 to 2021
$12.3M
IL-27 functions as a novel signal 3 cytokine and promotes cytotoxic T cell responses to tumorsK99CA290077 · NCI · HARVARD MEDICAL SCHOOL · PI Martin LaFleur · 2025 to 2026
$327k
Cancer Research Institute (CRI) CRI5009Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) U19AI133524NCI NIH HHS K99 CA290077NIAID NIH HHS P01 AI039671NIAID NIH HHS P01 AI108545NIAID NIH HHS U19 AI133524U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) 1K99CA290077-01A1
6 · The paper itself

Abstract

In vivo CRISPR screens in CD8

Indexed as

Adaptor Proteins, Signal TransducingCD8-Positive T-LymphocytesMelanoma, ExperimentalUbiquitin-Protein LigasesAnimalsCell Line, TumorHumansMiceMice, Inbred C57BLMice, KnockoutReceptors, CytokineAdaptor Proteins, Signal TransducingReceptors, CytokineUbiquitin-Protein Ligases

Identifiers

PMID40796662
PMCPMC12483072

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.