Evidence map›Paper›PMID 40796656›Full record

ArticleCommunications biology2025

Extracellular matrix deposition precedes muscle-tendon integration during murine forelimb morphogenesis.

Yue Leng, Sarah N Lipp, Ye Bu, Hannah Larson, Kathryn R Jacobson, Haley A Colling, Sarah Calve

Abstract read
In one paragraph

Article in Communications biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Testing cellular provenance in the cancer extracellular matrix.Frontiers in cell and developmental biology · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yue Leng *Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Sarah N Lipp *Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.ORCID http://orcid.org/0000-0001-6303-2956
Ye BuWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA.
Hannah LarsonPaul M. Rady Department of Mechanical Engineering, University of Colorado Boulder, Boulder, CO, USA.
Kathryn R JacobsonPurdue University Interdisciplinary Life Science Program, West Lafayette, IN, USA.
Haley A CollingDepartment of Integrative Physiology, University of Colorado Boulder, Boulder, CO, USA.
Sarah CalveWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, USA. sarah.calve@colorado.edu.ORCID http://orcid.org/0000-0002-7887-6307

Funding

Defining the mechanical link that unites the musculoskeletal system during limb developmentDP2AT009833 · NCCIH · UNIVERSITY OF COLORADO · PI CALVE, SARAH · 2017 to 2017
$2.2M
Biomechanical Influence of ECM Remodeling on the Developing EnthesisR01AR071359 · NIAMS · UNIVERSITY OF COLORADO · PI CALVE, SARAH · 2017 to 2021
$1.7M
Extracellular integration of a cohesive myotendinous junctionR01AR081090 · NIAMS · UNIVERSITY OF COLORADO · PI Sarah Calve · 2023 to 2026
$1.7M
NCCIH NIH HHS DP2 AT009833NIAMS NIH HHS R01 AR071359NIAMS NIH HHS R01 AR081090
6 · The paper itself

Abstract

The development of a functional musculoskeletal system requires the combination of contractile muscle and extracellular matrix (ECM)-rich tendons that transmit muscle-generated force to bone. Despite the different embryologic origins, muscle and tendon integrate at the myotendinous junction (MTJ) to connect across this interface. While the cell-cell signaling factors have received considerable attention, how the ECM links these tissues remains unclear. Here, we show the 3D distribution of ECM during forelimb development in wildtype (WT) and muscle-less Pax3

Indexed as

Extracellular MatrixForelimbMorphogenesisMuscle, SkeletalTendonsAnimalsMice

Identifiers

PMID40796656
PMCPMC12343929

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.