Evidence map›Paper›PMID 40796650›Full record

ArticleScientific reports2025

Andrographolide promotes the ex vivo expansion of CD34+ hematopoietic stem cells derived from human umbilical cord blood.

Nareerat Sutjarit, Laongthip Ruknarong, Chamnan Tanprasertkul, Kanit Bhukhai, Hay Man Saung Hnin Soe, Pakpoom Kheolamai, Sirikul Manochantr, Chairat Tantrawatpan, Duangrat Tantikanlayaporn

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nareerat Sutjarit *Nutrition Unit, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, 10400, Thailand.
Laongthip Ruknarong *Center of Excellence in Stem Research and Innovation, Thammasat University, Pathumthani, 12120, Thailand.
Chamnan TanprasertkulThammasat University Research Unit in Advanced Clinical Data Statistics Analysis and Innovative Research in Obstetrics and Gynecology Group, Pathumthani, 12120, Thailand.
Kanit BhukhaiDepartment of Physiology, Faculty of Science, Mahidol University, Bangkok, 10400, Thailand.
Hay Man Saung Hnin SoeCenter of Excellence in Stem Research and Innovation, Thammasat University, Pathumthani, 12120, Thailand.
Pakpoom KheolamaiCenter of Excellence in Stem Research and Innovation, Thammasat University, Pathumthani, 12120, Thailand.
Sirikul ManochantrCenter of Excellence in Stem Research and Innovation, Thammasat University, Pathumthani, 12120, Thailand.
Chairat TantrawatpanCenter of Excellence in Stem Research and Innovation, Thammasat University, Pathumthani, 12120, Thailand.
Duangrat TantikanlayapornCenter of Excellence in Stem Research and Innovation, Thammasat University, Pathumthani, 12120, Thailand. dkanlayaporn@gmail.com.

Funding

Thailand Science Research and Innovation Fundamental Fund TUFF35/2565Thammasat University Research Fund under the TU Research Scholar TUFT-FF 32/2565
6 · The paper itself

Abstract

Umbilical cord blood (UCB) units are an alternative source of human hematopoietic stem cells (HSCs) for allogeneic stem cell transplants. A large quantity of HSCs is needed but the low number of accessible cells from UCB has been a significant limitation. Improving the ex vivo growth of HSCs while preserving their functioning is required. Here, we report that andrographolide (AP) enhanced the expansion of human UCB-derived HSCs (HSPCs) and pro-moted primitive HSCs (CD34

Indexed as

Antigens, CD34DiterpenesFetal BloodHematopoietic Stem CellsCell DifferentiationCell ProliferationCells, CulturedHumansWnt Signaling PathwayandrographolideAntigens, CD34DiterpenesAndrographolideEx vivo expansionHematologic disordersHematopoietic stem cells (HSCs)Hematopoietic stem cell transplantationUmbilical cord blood (UCB)

Identifiers

PMID40796650
PMCPMC12343817

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.