Evidence map›Paper›PMID 40796646›Full record

ArticleScientific reports2025

Enhancing methyldopa solubility via green supercritical fluid techniques using ethanol co-solvent.

Hadil Faris Alotaibi, Suleiman Ibrahim Mohammad, Asokan Vasudevan, Suranjana V Mayani, Suhas Ballal, Munthar Kadhim Abosaoda, Abhayveer Singh, Subhashree Ray, Atreyi Pramanik

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hadil Faris AlotaibiDepartment of Pharmaceutical Sciences, College of Pharmacy, Princess Nourah Bint, AbdulRahman University, Riyadh, 11671, Saudi Arabia. Hfalotaibi@pnu.edu.sa.
Suleiman Ibrahim MohammadElectronic Marketing and Social Media, Economic and Administrative Sciences, Zarqa University, Zarqa, Jordan.
Asokan VasudevanFaculty of Business and Communications, INTI International University, Negeri Sembilan, 71800, Malaysia.
Suranjana V MayaniDepartment of Chemistry, Faculty of Science, Marwadi University Research Center, Marwadi University, Rajkot, Gujarat, India.
Suhas BallalDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to be University), Bangalore, Karnataka, India.
Munthar Kadhim AbosaodaCollege of pharmacy, the Islamic University, Najaf, Iraq.
Abhayveer SinghCentre for Research Impact & Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, 140401, Punjab, India.
Subhashree RayDepartment of Biochemistry, IMS and SUM Hospital, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, 751003, Odisha, India.
Atreyi PramanikSchool of Applied and Life Sciences, Division of Research and Innovation, Uttaranchal University, Dehradun, Uttarakhand, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study is to investigate the solubility of methyldopa in supercritical carbon dioxide. Solubility was examined at temperatures of 338, 328, 318, and 308 K, in both the presence and absence of a co-solvent. Specifically, ethanol was evaluated as a co-solvent. Semi-empirical and empirical approaches, as well as the Peng-Robinson equation, were applied to analyze the experimental data. The mole fraction (solubility) of methyldopa was found to range from 0.078 × 10

Indexed as

BinaryCarbon dioxideCorrelationSolubilityTernary

Identifiers

PMID40796646
PMCPMC12344082

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.