Evidence map›Paper›PMID 40796632›Full record

ArticleScientific reports2025

Cytoreductive nephroureterectomy for treatment of upper urinary tract urothelial carcinoma initially diagnosed as node-positive.

Shu-Yu Wu, Chi-Ping Huang, Chao-Hsiang Chang, Steven K Huang, Wen-Hsin Tseng, Wei-Ming Li, Hung-Lung Ke, I-Hsuan Alan Chen, Jen-Tai Lin, Jen-Shu Tseng and 19 more

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

29 authors.

Shu-Yu WuDepartment of Urology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
Chi-Ping HuangDepartment of Urology, China Medical University and Hospital, Taichung, Taiwan.
Chao-Hsiang ChangDepartment of Urology, China Medical University and Hospital, Taichung, Taiwan.
Steven K HuangDivision of Urology, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan.
Wen-Hsin TsengDivision of Urology, Department of Surgery, Chi Mei Medical Center, Tainan, Taiwan.
Wei-Ming LiDepartment of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
Hung-Lung KeDepartment of Urology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan.
I-Hsuan Alan ChenDivision of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Jen-Tai LinDivision of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.
Jen-Shu TsengDepartment of Urology, MacKay Memorial Hospital, Taipei, Taiwan.
Wun-Rong LinDepartment of Urology, MacKay Memorial Hospital, Taipei, Taiwan.
Yuan-Hong JiangDepartment of Urology, School of Medicine, Tzu Chi University, Hualien, Taiwan.
Yu-Khun LeeDepartment of Urology, School of Medicine, Tzu Chi University, Hualien, Taiwan.
Shian-Shiang WangDivision of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan.
Jian-Ri LiDivision of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung, Taiwan.
Wei-Chieh ChenDepartment of Urology, Taipei Medical University Hospital, Taipei Medical University, Taipei City, Taiwan.
Ting-En TaiDepartment of Urology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
Po-Hung LinDivision of Urology, Department of Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.
Thomas Y HsuehDivision of Urology, Department of Surgery, Taipei City Hospital Renal Branch, Taipei, Taiwan.
Hung-Keng LiDepartment of Life Science, School of Life Science, College of Science, National Taiwan Normal University, Taipei, Taiwan.
Pi-Che ChenDepartment of Urology, Ditmanson Medical Foundation Chiayi Christian Hospital, Chiayi, Taiwan.
Chao-Yuan HuangDepartment of Urology, College of Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan.
Yung-Tai ChenDepartment of Urology, Postal Hospital, Taipei, Taiwan.
Chia-Chang WuDepartment of Urology, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan.
Hsu-Che HuangDivision of Urology, Department of Surgery, Cardinal Tien Hospital, New Taipei City, 23148, Taiwan.
Wei-Yu LinDivision of Urology, Department of Surgery, Chang Gung Memorial Hospital, Chia-Yi, Taiwan.
Han-Yu WengDepartment of Urology, College of Medicine, National Cheng Kung University Hospital, National Cheng Kung University, Tainan, Taiwan.
Chi-Wen LoDepartment of Urology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan.
Yao-Chou TsaiDepartment of Urology, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. tsai1970523@yahoo.com.tw.

Funding

Buddhist Tzu Chi Medical Foundation TCMF-JCT-113-09Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation TCRD-TPE-112-12, TCRD-TPE-113-32
6 · The paper itself

Abstract

Urothelial carcinomas of the upper urinary tract (UTUC) are rare tumors with a high malignancy degree. Radical nephroureterectomy (RNU) with bladder cuff excision remains one of the standard treatments in clinically localized or locally advanced UTUCs. However, the role of cytoreductive RNU in treating clinically lymph node-positive (N+) UTUCs remains unclear. A nationwide retrospective study was conducted by the Taiwan UTUC Collaboration Group from July 1988 to June 2022. Patients with clinical N + UTUC before initiation of cancer therapy were included in this study. Initial clinically node-positive disease was noted in 288 (5.4%) of the 5,301 patients. Of the patients, 239 (83%) patients underwent RNU. UTUC-related mortality was markedly higher among patients not receiving RNU than among those who underwent surgery (69.4% vs. 36%). After adjusting for the effects of stepwise enrolled parameters, multivariate analysis showed that undergoing RNU (or not) and smoking (or not) were the only independent predictors of overall survival (OS). After adjusting for the effects of significant stepwise enrolled variables, multivariate analysis showed that RNU and smoking (or not) were the only independent predictors of cancer-specific survival (CSS). Our findings showed that RNU is associated with better OS and CSS in Taiwanese patients with N + UTUC. Common patient characteristics and most cancer characteristics were not related to the outcome. Our results provide new evidence on the efficacy of RNU for patients with N + UTUC, which could alter and guide the direction of future treatment guidelines.

Indexed as

Carcinoma, Transitional CellCytoreduction Surgical ProceduresNephroureterectomyUrologic NeoplasmsAdultAgedAged, 80 and overFemaleHumansLymphatic MetastasisMaleMiddle AgedRetrospective StudiesTaiwanLymph node metastasisOncological outcomesRadical nephroureterectomyUpper urinary tract urothelial carcinoma

Identifiers

PMID40796632
PMCPMC12344137

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.