Evidence map›Paper›PMID 40796626›Full record

ArticleScientific reports2025

Oral health and the risk of head and neck squamous cell carcinoma: a multicenter case-control study in Iran.

Hamideh Rashidian, Elham Mohebbi, Maryam Hadji, Mahin Gholipour, Monireh Sadat Seyyedsalehi, Ali Akbar Haghdoost, Paolo Boffetta, Sepideh Mokhtari, Kazem Zendehdel

Erratum issuedAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Hamideh RashidianCancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Elham MohebbiLombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Colombia, USA.
Maryam HadjiHealth unit, Faculty of Social Sciences, Tampere University, Tampere, Finland.
Mahin GholipourMetabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Islamic Republic of Iran.
Monireh Sadat SeyyedsalehiCancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran.
Ali Akbar HaghdoostResearch Centre for Modelling in Health, Institute for Future Studies in Health, Regional Knowledge HUB for HIV/AIDS Surveillance, Kerman University of Medical Sciences, Kerman, Islamic Republic of Iran.
Paolo BoffettaStony Brook Cancer Center, Stony Brook University, Stony Brook, NY, USA.
Sepideh MokhtariDepartment of Pathology, Cancer Institute, Imam Khomeini Hospital Complex (IKHC), School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. mokhtaris@sina.tums.ac.ir.
Kazem ZendehdelCancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. kzendeh@sina.tums.ac.ir.

Funding

National Institute for Medical Research Development (NIMAD) 940045
6 · The paper itself

Abstract

The current study aimed to assess the independent effect of a high Decayed, Missing, and Filled Teeth (DMFT) score on the risk of head and neck squamous cell carcinoma (HNSCC) overall and its subsites. Also, we tested for the interaction effect of smoking tobacco and opium with the DMFT score on the risk of developing HNSCC. We included 899 pathologically confirmed cases of HNSCC and 3477 healthy visitor controls. We used multivariable unconditional logistic regression analyses to estimate odds ratios (ORs) and 95% confidence intervals (CIs) adjusted for study centers, age, sex, socioeconomic status, and alcohol, cigarettes, water pipes, and opium use. We found an OR of 2.0 (95% CI: 1.6, 2.5) between DMFT scores higher than 17 and the risk of HNSCC. This was higher for laryngeal (OR: 3.6, 95% CI: 2.5, 5.2) than lip oral cavity (OR: 1.5, 95% CI: 1.2, 2.0) cancers. We found a positive association between Decayed and Missing teeth, however, it was reversed for the number of Filled teeth. The association for those who had higher DMFT score was significantly higher (OR: 2.3, 95%CI: 1.7, 3.0) among smokers than non-smokers (OR: 1.7, 95% CI: (1.2, 2.3). A higher DMFT score was associated with an increased risk of HNSCC, with an interaction between DMFT score and smoking.

Indexed as

Head and Neck NeoplasmsOral HealthSquamous Cell Carcinoma of Head and NeckAdultAgedCase-Control StudiesFemaleHumansIranMaleMiddle AgedOdds RatioRisk FactorsSmokingHNSCCOpiumOral healthTobacco

Identifiers

PMID40796626
PMCPMC12343843

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.