ArticleScientific reports2025
Quality-of-life changes six months after the programmatic switch from nevirapine to dolutegravir-based ART in stable PLWH: a prospective cohort study in Indonesia.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Impact of Dolutegravir-based regimens on patient satisfaction and quality of life among people living with HIV: a systematic review and meta-analysis.BMC infectious diseases · 2026Pooled it
- Depression, Medication Adherence, and Beliefs as Determinants of Health-Related Quality of Life among People Living with HIV: A Cross-Sectional Pharmacoepidemiologic Study in Indonesia.Journal of the International Association of Providers of AIDS CareArticle
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Authors and funding
7 authors.
Funding
Abstract
Indonesia has implemented a programmatic transition of nevirapine to a dolutegravir-based antiretroviral therapy for stable people living with HIV (PLWH). This study aimed to identify changes in quality of life (QoL) after six months of this transition and evaluate the correlation of weight, sleep quality, depression, and estimated glomerular filtration rate (eGFR) changes to QoL. Our cohort prospective study involved 145 participants who underwent transition from nevirapine to dolutegravir-based regimen. QoL was assessed using the Indonesian version of the EQ-5D-3 L questionnaire. Of the 145 participants, 57.2% were male, with a median age of 43 (40-46.5) years, and 99.3% had undetectable viruses. We found a significant improvement in EQ VAS score (median 90 (IQR 80-99) vs. median 90 (IQR 85-100), p = < 0.001). There was, however, a significant number of participants who had worsening pain/discomfort (p = 0.036). We found no correlation between changes in weight, sleep quality, depression, and eGFR with QoL. Our study shows a promising improvement in QoL as a result of transitioning from nevirapine to dolutegravir-based regimen despite an increase in reported pain.
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