Evidence map›Paper›PMID 40796564›Full record

ArticleScientific reports2025

miRNA-204-5p acts as a tumor suppressor in gastric cancer by inhibiting cell migration, invasion, and glycolysis via the RAB22A/PI3K/AKT axis.

Wen Pan, Ying Tan, Xiaohong Chen, Li Zeng, Yuetong Lv, Jinlin Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wen PanDepartment of Health Management Center, The Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region, Ximianqiao Street No.20, Chengdu, 610041, Sichuan, China.
Ying TanDepartment of Gastroenterology and Hepatology, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Chengdu, 610041, Sichuan, China.
Xiaohong ChenDepartment of Gastroenterology and Hepatology, The Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region, Ximianqiao Street No.20, Chengdu, 610041, Sichuan, China.
Li ZengDepartment of Health Management Center, The Hospital of Chengdu Office of People's Government of Tibetan Autonomous Region, Ximianqiao Street No.20, Chengdu, 610041, Sichuan, China.
Yuetong LvZhongnan Hospital of Wuhan University (The second Clinical School of Wuhan University), Wuhan University, No.169 Donghu Road, Wuhan, 430071, Hubei, China.
Jinlin YangDepartment of Gastroenterology and Hepatology, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Chengdu, 610041, Sichuan, China. yangjinlin@wchscu.cn.ORCID http://orcid.org/0000-0001-8726-7258

Funding

Local projects based on central guidance of China XZ202301YD0031C
6 · The paper itself

Abstract

Gastric cancer (GC) is a highly prevalent and lethal malignancy worldwide. Accumulating evidence has shown that microRNAs (miRNAs) play essential roles in the development and progression of GC. In this study, we aimed to investigate the expression, functions, and molecular mechanisms of miRNA-204-5p in GC. We found that miRNA-204-5p was significantly downregulated in GC cell lines compared to their normal counterparts. Functional experiments demonstrated that miRNA-204-5p inhibited the migration, invasion, and glycolysis of GC cells in vitro and suppressed tumor lung metastasis in vivo. Mechanistically, miRNA-204-5p exerted its tumor-suppressive effects by directly targeting RAB22A and inhibiting the PI3K/AKT signaling pathway. Overexpression of RAB22A partially reversed the inhibitory effects of miRNA-204-5p on the malignant phenotypes and the PI3K/AKT pathway activation in GC cells. Furthermore, miRNA-204-5p regulated the expression of molecules related to epithelial-mesenchymal transition, and glycolysis through the RAB22A/PI3K/AKT axis. Our findings suggest that miRNA-204-5p functions as a tumor suppressor in GC by targeting RAB22A and provide novel insights into the molecular mechanisms underlying GC progression. The miRNA-204-5p/RAB22A axis may serve as a potential diagnostic biomarker and therapeutic target for GC.

Indexed as

GlycolysisMicroRNAsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktrab GTP-Binding ProteinsStomach NeoplasmsAnimalsCell Line, TumorCell MovementEpithelial-Mesenchymal TransitionGene Expression Regulation, NeoplasticGenes, Tumor SuppressorHumansMiceMice, NudeNeoplasm InvasivenessMicroRNAsMIRN204 microRNA, humanPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRAB22A protein, humanrab GTP-Binding ProteinsGastric cancerGlycolysisInvasionMigrationmiRNA-204-5pPI3K/AKT signaling pathwayRAB22A

Identifiers

PMID40796564
PMCPMC12343757

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.