Evidence map›Paper›PMID 40796509›Full record

ArticleJournal of medicinal chemistry2025

Conformational Restriction of Designer Drugs Reveals Subtype-Selective and Biased CB

Claudia Gioé-Gallo, Sandra Ortigueira, Rubén Prieto-Díaz, Marialessandra Contino, Jhonny Azuaje, Maria Grazia Perrone, Chiara Riganti, Domenico Alberga, Giuseppe Felice Mangiatordi, Antonio Andújar-Arias and 15 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Synthesis of Novel Chloro-Benzo [Pharmaceuticals (Basel, Switzerland) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Claudia Gioé-GalloCentro Singular de Investigación en Química Biolóxica y Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Sandra OrtigueiraCentro Singular de Investigación en Química Biolóxica y Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Rubén Prieto-DíazCentro Singular de Investigación en Química Biolóxica y Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0000-0003-2539-3106
Marialessandra ContinoDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari ALDO MORO, via Orabona 4, 70125 Bari, Italy.ORCID 0000-0002-0713-3151
Jhonny AzuajeCentro Singular de Investigación en Química Biolóxica y Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Maria Grazia PerroneDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari ALDO MORO, via Orabona 4, 70125 Bari, Italy.ORCID 0000-0003-4195-5228
Chiara RigantiDipartimento di Oncologia, Università degli Studi di Torino, piazza Nizza 44, 10126 Torino, Italy.ORCID 0000-0001-9787-4836
Domenico AlbergaCNR - Institute of Crystallography, Via Giovanni Amendola, 122/O, 70126 Bari, Italy.ORCID 0000-0002-9475-9602
Giuseppe Felice MangiatordiCNR - Institute of Crystallography, Via Giovanni Amendola, 122/O, 70126 Bari, Italy.ORCID 0000-0003-4042-2841
Antonio Andújar-AriasCentro Singular de Investigación en Química Biolóxica y Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0000-0001-9922-3543
Aitor García-ReyCentro Singular de Investigación en Química Biolóxica y Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Giovanni GrazianoCentro Singular de Investigación en Química Biolóxica y Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0000-0002-5575-3240
Angela StefanachiDipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari ALDO MORO, via Orabona 4, 70125 Bari, Italy.ORCID 0000-0002-9430-7972
Cristina ValCentro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Antón Leandro MartínezCentro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0000-0002-1595-3459
Joan Biel RebassaDepartment of Biochemistry and Physiology, School of Pharmacy and Food Science, Universitat de Barcelona, Institut de Neurosciències UB, Barcelona 08028, Spain.
David RezaCentro Singular de Investigación en Química Biolóxica y Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Asier SelasCentro Singular de Investigación en Química Biolóxica y Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.
Fabio FrancavillaCentro Singular de Investigación en Química Biolóxica y Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0009-0004-3921-7597
M Rita PaleoCentro Singular de Investigación en Química Biolóxica y Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0000-0002-0095-3931
Xerardo García-MeraCentro Singular de Investigación en Química Biolóxica y Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0000-0001-5218-6351
M Isabel LozaCentro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0000-0003-4730-0863
Gemma NavarroDepartment of Biochemistry and Physiology, School of Pharmacy and Food Science, Universitat de Barcelona, Institut de Neurosciències UB, Barcelona 08028, Spain.
José BreaCentro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0000-0002-5523-1979
Eddy SoteloCentro Singular de Investigación en Química Biolóxica y Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Spain.ORCID 0000-0001-5571-2812

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study presents the design, synthesis, and characterization of a novel series of structurally simple, selective, and functionally biased CB

Indexed as

Designer DrugsNeuroprotective AgentsReceptor, Cannabinoid, CB2AnimalsApoptosisDrug DesignHumansMiceMolecular ConformationNeuronsStructure-Activity RelationshipDesigner DrugsNeuroprotective AgentsReceptor, Cannabinoid, CB2

Identifiers

PMID40796509
PMCPMC12406204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.