Evidence map›Paper›PMID 40796492›Full record

Observational studyBritish journal of anaesthesia2025

Vasopressor use after noncardiac surgery: an international observational study.

Ib Jammer, Peter Martin, Hannah Wunsch, Sophie Debouche, Pierre Harlet, Ramani Moonesinghe, Lui Forni, Ben Creagh-Brown, Writing committee for the Squeeze investigators

Registry-linked trialAbstract readObservational StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in British journal of anaesthesia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03805230 (Postoperative Vasopressor Usage), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03805230 completednot on this map

Postoperative Vasopressor Usage : a Prospective International Observational Study (SQUEEZE)

TypeobservationalSponsorEuropean Society of AnaesthesiologyRan2020 to 2024Enrolled25,000ConditionsSurgical Procedures, Operative, Vasopressor
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Observational
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ib JammerDepartment of Anaesthesia and Intensive Care, Haukeland University Hospital, Bergen, Norway. Electronic address: Ib.jammer@helse-bergen.no.
Peter MartinInstitute of Epidemiology and Health Care, University College London, London, UK.
Hannah WunschDepartment of Anesthesiology, Weill Cornell Medicine, New York, NY, USA; Department of Anesthesiology and Pain Medicine, University of Toronto, Toronto, ON, Canada.
Sophie DeboucheEuropean Society of Anaesthesiology and Intensive Care, Brussels, Belgium.
Pierre HarletEuropean Society of Anaesthesiology and Intensive Care, Brussels, Belgium.
Ramani MoonesingheCentre for Perioperative Medicine, University College London, London, UK.
Lui ForniIntensive Care Unit, Royal Surrey County Hospital, Guildford, UK; School of Medicine, University of Surrey, Guildford, UK.
Ben Creagh-BrownIntensive Care Unit, Royal Surrey County Hospital, Guildford, UK; School of Medicine, University of Surrey, Guildford, UK.
Writing committee for the Squeeze investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypotension after major noncardiac surgery is associated with increased morbidity, mortality, and costs, and is often treated with postoperative vasopressor infusions. The frequency of administration in the postoperative period is unknown.

methodsThis international prospective cohort study was conducted between October 2020 and October 2023. At each hospital, adults undergoing noncardiac surgery were enrolled into two cohorts: all consecutive patients for 1 week (Cohort A) and an additional sample of up to 30 consecutive patients administered postoperative vasopressor infusions within 1 yr (Cohort B). The primary outcome (Cohort A) was the incidence of postoperative vasopressor infusions, defined as any continuous infusion of vasopressors. Secondary outcomes included in-hospital mortality, organ dysfunction, length of hospital stay, and complications associated with postoperative vasopressor infusions (both cohorts).

resultsIn total, 25 675 participants were enrolled from 228 hospitals across 42 countries. In Cohort A, 770/19 768 (3.9%) participants received postoperative vasopressor infusions, with vasopressor use ranging between 0% and 18% across hospitals (median odds ratio: 2.30 [credible interval 1.96-2.73]). This variability did not alter after adjustment for case-mix and procedural characteristics. For both cohorts, postoperative vasopressor infusions were associated with higher (15.5%) in-hospital mortality, higher rates of organ failure, and longer hospital stay.

conclusionsAdministration of postoperative vasopressors after noncardiac surgery varied across hospitals and was associated with worse outcomes. Variable practice across hospitals could not be explained by differences in case-mix. CLINICAL

trial registrationhttps://clinicaltrials.gov/study/NCT03805230, ESAIC tracking ID: ESAIC_CTN_SQUEEZE.

Indexed as

HypotensionPostoperative CarePostoperative ComplicationsSurgical Procedures, OperativeVasoconstrictor AgentsAdultAgedCohort StudiesFemaleHospital MortalityHumansLength of StayMaleMiddle AgedProspective StudiesVasoconstrictor Agentshaemodynamicnoradrenalineperioperative medicinepostoperative hypotensionvasoconstrictorsvasoplegiavasopressors

Identifiers

PMID40796492
PMCPMC12799376

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.