ArticleJournal of clinical periodontology2025
Oral Microbiota Linking Humoral Response, Periodontitis and Atherosclerosis.
Article in Journal of clinical periodontology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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The trial behind it
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Who cites it
9 citing papers in PubMed.
- Periodontal Dysbiosis and Premature Atherosclerosis: A Critical Appraisal of the Oral-Gut-Vascular Axis.Biomedicines · 2026Review
- The redefined identity ofJournal of bacteriology · 2026Review
- Salivary IgA and dentine caries in relation to physical activity and fitness: A cohort-based cross-sectional study.Clinical oral investigations · 2026Article
- The Oral Microbiome and Systemic Health: Current Insights into the Mouth-Body Connection.Life (Basel, Switzerland) · 2026Review
- Biological properties and potential pathogenic mechanisms of oral bacterial-derived extracellular vesicles in oral and systemic diseases.Extracellular vesicles and circulating nucleic acids · 2026Review
- Periodontitis and systemic diseases: insights into the correlation, mechanisms, and clinical implications.Frontiers in immunology · 2026Review
- The oral - X axis: from periodontal dysbiosis to systemic disease.Frontiers in immunology · 2026Review
- Oral Microbiota Linking Humoral Response, Periodontitis and Atherosclerosis.Journal of clinical periodontology · 2025Article
- Oral microbiota in cardiovascular health and disease.Frontiers in cellular and infection microbiology · 2025Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
aimThe humoral immune system is implicated in the link between periodontitis and atherosclerosis. This study aims to explore how interactions between the oral microbiota and humoral immune responses may contribute to this association. MATERIALS AND
methodsWe analysed data from the Northern Finland Birth Cohort 1966, which included 1560 participants who underwent comprehensive health and oral examinations. Serum antibodies against phosphorylcholine (PCho) and malondialdehyde acetaldehyde (MAA) adducts were measured using chemiluminescence immunoassays. In a sub-cohort (n = 868), the oral microbiome from saliva samples was characterised using 16S rRNA gene sequencing.
resultsHigher serum levels of IgA and IgG to PCho, as well as IgA to MAA, were associated with an increased number of teeth with probing pocket depths (PPD) ≥ 4 mm. Several oral bacterial species, including Prevotella dentalis , Filifactor alocis and Treponema denticola , correlated with both PPD ≥ 4 mm and IgA/IgG responses to PCho. Mediation analysis, adjusted for periodontitis risk factors, identified F. alocis as a mediator linking elevated plasma IgG to PCho with the number of teeth with PPD ≥ 4 mm. Additionally, individuals harbouring F. alocis exhibited increased carotid intima-media thickness.
conclusionsOur findings suggest that F. alocis may serve as a microbial link between periodontitis and atherosclerosis. Future mechanistic studies should investigate how F. alocis induces systemic IgG responses and contributes to atherosclerosis.
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