ReviewJournal of leukocyte biology2025
The function of metalloproteinases in pathophysiology of inflammatory bowel disease and colon cancer.
Review in Journal of leukocyte biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Effects of personalized vitamin DBritish journal of cancer · 2026Trial
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Inflammatory bowel disease (IBD) is a debilitating and symptomatic disorder of the gastrointestinal tract, featuring dysregulated inflammation, intestinal injury, and barrier dysfunction. IBD is also a risk factor for colorectal cancer (CRC), which remains a leading cause of cancer-related mortalities worldwide. Matrix metalloproteinases (MMPs) are a diverse family of proteases that play critical roles in both intestinal homeostasis and disease pathogenesis. Produced by epithelial, stromal, and immune cells, MMPs can regulate stem cell function, immune cell recruitment, microbial composition, barrier integrity, angiogenesis, and cell proliferation through extracellular matrix remodeling, cytokine activation, or direct interactions with target cells, thereby impacting the progression of both IBD and CRC. In this review we discuss the roles of MMPs in the maintenance of intestinal homeostasis and their contributions to imbalanced immune responses, epithelial integrity, and wound healing in IBD. Additionally, we highlight their contribution to epithelial-to-mesenchymal transition, angiogenesis, and metastasis in CRC. Finally, we review the potential utilization of MMPs as biomarkers for IBD/CRC diagnosis, prognosis, and treatment response. MMPs remain central to both IBD and CRC biology and present both challenges and opportunities for therapeutic intervention and disease monitoring.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.