Evidence map›Paper›PMID 40795973›Full record

ArticleProceedings. Biological sciences2025

The hedonic impact of cleaner-client fish interactions is mediated by the opioid system.

Caio Maximino, Heloysa Araujo-Silva, Inês Cacela-Rodrigues, Ana C Luchiari, João L Saraiva, Marta C Soares

Abstract read
In one paragraph

Article in Proceedings. Biological sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Caio MaximinoLaboratory of Neurosciences and Behavior "Frederico Guilherme Graeff", Faculty of Psychology, Institute of Health and Biological Studies, Federal University of the South and Southeast of Pará, Marabá 68500-000, Brazil.ORCID 0000-0002-3261-9196
Heloysa Araujo-SilvaFishLab, Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal 59078-900, Brazil.ORCID 0000-0002-3868-866X
Inês Cacela-RodriguesCIBIO, Research Centre in Biodiversity and Genetic Resources, University of Porto, InBIO Associate Laboratory, Vairão, Porto 4485-661, Portugal.ORCID 0009-0002-4693-1946
Ana C LuchiariFishLab, Department of Physiology and Behavior, Federal University of Rio Grande do Norte, Natal 59078-900, Brazil.ORCID 0000-0003-3294-7859
João L SaraivaFish Etho Group Association, Faro 8005-226, Portugal.ORCID 0000-0002-8891-8881
Marta C SoaresCIBIO, Research Centre in Biodiversity and Genetic Resources, University of Porto, InBIO Associate Laboratory, Vairão, Porto 4485-661, Portugal.ORCID 0000-0002-5213-2377

Funding

CEECCNPq/National Council of Science and TechnologyFisheries SocietyFoundation for Science and TechnologyNational Council for Scientific and Technological Development
6 · The paper itself

Abstract

According to the 'incentive salience hypothesis' reward processing involves two main components, including the motivation to obtain a reward (i.e. incentive salience or 'wanting') and the hedonic pleasure felt during its consumption (i.e. hedonic impact or 'liking'), which are dissociable. The processing of these hedonic mechanisms is suggested to be mediated by opioid neurotransmission; however, most evidence comes from humans and other mammals. Here we argue that, in mutualistic associations, client fish seek to interact with cleaner fish not only due to the immediate benefits of being cleaned but also because of the hedonic impact of tactile stimulation, modulated by the opioid system. We used a conditioned place preference (CPP) paradigm to test the hedonic dimension of motivation to be cleaned and found that de-parasitized client fish (the butterflyfish

Indexed as

Analgesics, OpioidPerciformesReceptors, Opioid, muAnimalsEnkephalin, Ala(2)-MePhe(4)-Gly(5)-MotivationNaloxoneNarcotic AntagonistsRewardAnalgesics, OpioidEnkephalin, Ala(2)-MePhe(4)-Gly(5)-NaloxoneNarcotic AntagonistsReceptors, Opioid, mucleaning mutualismsconditioned place preferencedetourhedonic motivationopioid neurotransmissionteleost fish

Identifiers

PMID40795973
PMCPMC12343142

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.