Evidence map›Paper›PMID 40795965›Full record

ArticleInternational health2026

Adaptation of Inuka coaching problem-solving therapy to support mental health and HIV medication adherence among status-neutral men who have sex with men in South Africa.

Lindiwe Tsope, Elise M van der Elst, Jacqueline Pienaar, Charlene Denousse, Mapaseka Mabena, Pontsho Komane, Boitumelo Ramashala, Ankiza Gakunu, Danielle Giovenco, Ruwenne Moodley and 2 more

Abstract read
In one paragraph

Article in International health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lindiwe TsopeImplementation Science Division, The Aurum Institute, Johannesburg 2194, South Africa.
Elise M van der ElstDepartment of Interdisciplinary Social Science, Utrecht University, Utrecht, The Netherlands.
Jacqueline PienaarImplementation Science Division, The Aurum Institute, Johannesburg 2194, South Africa.
Charlene DenousseInuka Foundation, Nairobi, Kenya.
Mapaseka MabenaImplementation Science Division, The Aurum Institute, Johannesburg 2194, South Africa.
Pontsho KomaneImplementation Science Division, The Aurum Institute, Johannesburg 2194, South Africa.
Boitumelo RamashalaImplementation Science Division, The Aurum Institute, Johannesburg 2194, South Africa.
Ankiza GakunuInuka Foundation, Nairobi, Kenya.
Danielle GiovencoBehavior, Social and Health Education Sciences, Emory University, Georgia 30322, USA.
Ruwenne MoodleyBehavior, Social and Health Education Sciences, Emory University, Georgia 30322, USA.
Don OperarioBehavior, Social and Health Education Sciences, Emory University, Georgia 30322, USA.
Eduard J SandersImplementation Science Division, The Aurum Institute, Johannesburg 2194, South Africa.ORCID 0000-0002-1062-8921

Funding

Addressing mental health and medication adherence among MSM in South AfricaR34MH135806 · NIMH · EMORY UNIVERSITY · PI DON OPERARIO, Eduard Sanders · 2024 to 2026
$567k
Aurum InstituteEuropean UnionGates Foundation INV-033558Gilead Sciences Inc. 19275NIMH NIH HHS R34 MH135806NIMH NIH HHS R34MH135806Science for Africa Foundation Del-22-007UK Foreign, Commonwealth & Development OfficeWellcome Trust
6 · The paper itself

Abstract

backgroundDepression is prevalent among men who have sex with men (MSM) in South Africa and can impact their adherence to PrEP and ART. We developed the WeCare coaching intervention, adapted from the evidence-based Friendship Bench/Inuka problem-solving therapy program, to address their mental health challenges.

methodsTwenty MSM with symptoms of mild to moderate depression (Patient Health Questionnaire-9 scores 5-14) and using PrEP or ART were recruited from two clinics in Johannesburg and Pretoria. Participants received adapted Inuka coaching (four individual and up to four group sessions). Mental health outcomes were assessed preintervention and postintervention using the SRQ-20. Postintervention in-depth interviews and focus group discussions were conducted with participants and lay health workers (LHWs). Qualitative data evaluated utility. Data were analysed using thematic analysis.

resultsMedian SRQ-score improved from preintervention to post-intervention assessment (p<0.001). Participants found coaching acceptable, qualitatively highlighting the value of a safe space to discuss emotional well-being. Key themes included: (1) need for cultural and contextual adaptation of coaching content; (2) stigma-related stressors shaping mental health and perceived engagement with ART/PrEP; and (3) LHWs expressed enthusiasm for delivering support but requested strengthened ART/PrEP literacy training.

conclusionFindings supported acceptability and feasibility and informed further development of the WeCare intervention.

Indexed as

DepressionHIV InfectionsHomosexuality, MaleMedication AdherenceMental HealthMentoringProblem SolvingAdultAnti-HIV AgentsFocus GroupsHumansMaleMiddle AgedSouth AfricaAnti-HIV AgentsdepressionInuka coachingmedication adherencemental healthMSMSouth Africa

Identifiers

PMID40795965
PMCPMC13016760

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.