Evidence map›Paper›PMID 40795938›Full record

ArticleCancer control : journal of the Moffitt Cancer Center

Analysis of HPV and NKG2D rs1049174 Polymorphism in Vietnamese Patients With Oropharyngeal Squamous Cell Carcinoma.

Nguyen Van Hung, Nguyen Hoang Viet, Do Trung Duc, Tran The Dieu, Nguyen Thanh Binh, Le Huy Hoang, Nguyen Quang Trung

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Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Nguyen Van HungCenter of ENT and Cochlear Implanted Surgery, Hanoi Medical University Hospital, Hanoi, Vietnam.
Nguyen Hoang VietMolecular Pathology Department, Faculty of Medical Technology, Hanoi Medical University, Hanoi, Vietnam.ORCID 0009-0002-5216-2282
Do Trung DucCenter of ENT and Cochlear Implanted Surgery, Hanoi Medical University Hospital, Hanoi, Vietnam.ORCID 0009-0004-3806-4453
Tran The DieuCenter of ENT and Cochlear Implanted Surgery, Hanoi Medical University Hospital, Hanoi, Vietnam.
Nguyen Thanh BinhHanoi Medical University, Hanoi, Vietnam.
Le Huy HoangDepartment of Bacteriology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam.ORCID 0009-0000-0434-3113
Nguyen Quang TrungOtorhinolaryngology Department, Hanoi Medical University, Hanoi, Vietnam.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IntroductionOropharyngeal Squamous Cell Carcinoma (OPSCC) etiology involves environmental and genetic factors, with Human Papillomavirus (HPV) being a key ecological driver. This study evaluated the relative importance of environmental factors, particularly HPV status, and the genetic polymorphism NKG2D rs1049174 in OPSCC among a Vietnamese population.MethodsA retrospective case-control study was conducted with 279 OPSCC patients and 250 healthy controls. HPV DNA was screened and typed using PCR and Sanger sequencing. Genotyping of NKG2D rs1049174 was performed using TaqMan assays. Logistic regression, Kaplan-Meier survival analysis, Cox proportional hazards regression, and Random Forest analysis were employed to assess associations between risk factors, genotype, clinical stage, survival, and HPV status.ResultsHPV status strongly predicted overall survival (OS), with HPV-positive patients exhibiting significantly longer survival (adjusted Hazard Ratio (aHR) = 0.32,

Indexed as

NK Cell Lectin-Like Receptor Subfamily KOropharyngeal NeoplasmsPapillomavirus InfectionsSquamous Cell Carcinoma of Head and NeckAdultAgedCarcinoma, Squamous CellCase-Control StudiesFemaleGenotypeHumansKaplan-Meier EstimateMaleMiddle AgedPolymorphism, Single NucleotideRetrospective StudiesKLRK1 protein, humanNK Cell Lectin-Like Receptor Subfamily Khuman papillomavirus (HPV)NKG2D rs1049174oropharyngeal squamous cell carcinoma (OPSCC)survival analysisVietnamese population

Identifiers

PMID40795938
PMCPMC12344339

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.