ArticleJournal of the National Cancer Institute. Monographs2025
Lung cancer incidence trends by histology and individual- and county-level sociodemographic characteristics in the United States from 2000 to 2019.
Article in Journal of the National Cancer Institute. Monographs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Stage-Survival Paradox in Young-Onset Lung Adenocarcinoma Patients Among Asian and Pacific Islander Women: A Population-Based Analysis.Journal of racial and ethnic health disparities · 2026Article
- Conditional dependence of the "male-SCC, female-ADC" teaching heuristic in lung cancer: shifts in exposure pathways and the need for pathology education reform.Frontiers in public health · 2026Article
- Dynamics that predispose, enable, and reinforce commercial tobacco-related health disparities: Introduction to a Monograph.Journal of the National Cancer Institute. Monographs · 2025Article
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Abstract
backgroundLung cancer incidence has been decreasing in the United States, largely due to smoking reductions. However, adenocarcinoma incidence has been relatively stable compared with other histological subtypes. Histology-specific lung cancer incidence varies by key sociodemographic characteristics, but trends are not well characterized.
methodsSEER 17 registry data was used to calculate annual age-adjusted lung cancer incidence over 2000-2019 by histology stratified by individual-level sex and race/ethnicity and county-level education, poverty, or urbanicity. Histology was categorized into 4 groups: adenocarcinoma, small cell, squamous cell, and other histologies. Age-adjusted incidence rates were computed using the 2000 US Standard Population. Incidence trends were characterized using Joinpoint regression.
resultsFor most histological subtypes, lung cancer incidence has been decreasing since 2000 in both sexes and all racial/ethnic groups, with some variations. However, lung adenocarcinoma incidence was relatively constant. Lung cancer incidence decreases with increasing education and income. It is lower in urban vs rural areas across histological subtypes, except for adenocarcinoma among females. Counties with higher education levels or lower poverty rates experienced faster declines in small cell and squamous cell lung cancer incidence in recent years. The incidence of small cell and squamous cell lung cancer has been decreasing more rapidly in urban than rural areas.
conclusionDisadvantaged groups have higher lung cancer rates and slower decreases in incidence over time for most histological subtypes, resulting in widening disparities. This highlights the need for targeted tobacco and lung cancer prevention strategies to accelerate decreases in vulnerable populations.
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