Evidence map›Paper›PMID 40795887›Full record

ArticleJournal of radiation research2025

Assessment of prognostic value and development of predictive model for prolonged lymphopenia in patients with glioblastoma following chemoradiotherapy.

Shuhei Takahashi, Kentaro Nishioka, Takashi Mori, Shigeru Yamaguchi, Yukitomo Ishi, Keiji Kobashi, Yoichi M Ito, Zen-Ichi Tanei, Hiromi Kanno-Okada, Shinya Tanaka and 1 more

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Article in Journal of radiation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shuhei TakahashiDepartment of Radiation Oncology, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo 060-8638, Japan.ORCID 0009-0008-4742-4325
Kentaro NishiokaGlobal Center for Biomedical Science and Engineering, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo 060-8638, Japan.ORCID 0000-0002-8272-7603
Takashi MoriDepartment of Radiation Oncology, Hokkaido University Hospital, Kita 14, Nishi 6, Kita-ku, Sapporo 060-8648, Japan.ORCID 0000-0001-5246-215X
Shigeru YamaguchiDepartment of Neurosurgery, Faculty of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo 060-8638, Japan.
Yukitomo IshiDepartment of Neurosurgery, Faculty of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo 060-8638, Japan.
Keiji KobashiGlobal Center for Biomedical Science and Engineering, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo 060-8638, Japan.ORCID 0000-0002-5471-8128
Yoichi M ItoData Science Center, Promotion Unit, Institute of Health Science Innovation for Medical Care, Hokkaido University Hospital, Kita 14, Nishi 6, Kita-ku, Sapporo 060-8648, Japan.ORCID 0000-0001-5073-0827
Zen-Ichi TaneiDepartment of Cancer Pathology, Faculty of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo 060-8638, Japan.
Hiromi Kanno-OkadaDepartment of Surgical Pathology, Hokkaido University Hospital, Kita 14, Nishi 6, Kita-ku, Sapporo 060-8648, Japan.
Shinya TanakaDepartment of Cancer Pathology, Faculty of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo 060-8638, Japan.ORCID 0000-0001-6470-3301
Hidefumi AoyamaDepartment of Radiation Oncology, Graduate School of Medicine, Hokkaido University, Kita 15, Nishi 7, Kita-ku, Sapporo 060-8638, Japan.

Funding

Japan Society for the Promotion of Science KAKENHI 21K15818
6 · The paper itself

Abstract

Lymphopenia during chemoradiotherapy (CRT) for glioblastoma has been shown to be a poor prognostic factor. However, the relationship between prolonged lymphopenia (PL) after CRT and prognosis remains unclear. This study aimed to explore the relationship between PL and glioblastoma prognosis and develop a predictive model for PL risk. We analyzed 87 patients with primary glioblastoma who underwent postoperative CRT with 60 Gy in 30 fractions of radiotherapy and temozolomide. PL was defined as grade 2 or higher lymphopenia 1 month after the completion of CRT. We conducted survival analysis, identified risk factors for PL, and developed a predictive model for PL risk. Of the 87 patients, 41 developed PL, and progression-free survival (PFS) was significantly shorter in the PL group (median 8.0 months vs 15.4 months, P = 0.003). However, there was no significant difference in overall survival between the two groups. PL was also a significant factor for shorter PFS in multivariable analysis (P = 0.040). Brain V20Gy (percentage of brain volume receiving ≥20 Gy), gross total resection (GTR), and preoperative Karnofsky performance status (KPS) were identified as significant risk factors for PL. The predictive model showed that the risk of PL could be predicted by brain V20Gy, sex, age, GTR and preoperative KPS. PL was identified as a PFS shortening factor. Our model suggests that reducing irradiated brain volume may help prevent PL and could potentially improve glioblastoma prognosis by preserving cancer immunity.

Indexed as

Brain NeoplasmsChemoradiotherapyGlioblastomaLymphopeniaAdultAgedFemaleHumansMaleMiddle AgedPrognosisRisk Factorscancer immunityglioblastomalymphopeniapredictive modelradiotherapy

Identifiers

PMID40795887
PMCPMC12460052

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.