ArticleCell2025
Molecular and neural control of social hierarchy by a forebrain-thalamocortical circuit.
Article in Cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Adolescent social isolation creates a latent vulnerability in maternal care with intergenerational social consequences, rescued by experienced mothers.bioRxiv : the preprint server for biology · 2026Article
- Neural circuits regulating social dominance implement a strategy predicted by evolutionary game theory.bioRxiv : the preprint server for biology · 2026Article
- Submedius thalamic inputs shape the presynaptic architecture of layer 5 orbitofrontal cortex in mice.iScience · 2026Article
- 7T multimodal MRI reveals structural-functional-quantitative susceptibility mapping abnormalities of new daily persistent headache.The journal of headache and pain · 2025Article
- Simultaneous detection and estimation in olfactory sensing.bioRxiv : the preprint server for biology · 2025Article
- A neurogenetic mechanism of experience-dependent suppression of aggression.Science advances · 2022Article
- Distinct Roles for Prefrontal Dopamine D1 and D2 Neurons in Social Hierarchy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Experiential modulation of social dominance in a SYNGAP1 rat model of Autism Spectrum Disorders.The European journal of neuroscience · 2021Article
- An Adolescent Sensitive Period for Social Dominance Hierarchy Plasticity Is Regulated by Cortical Plasticity Modulators in Mice.Frontiers in neural circuits · 2021Article
- Atypical social behaviors in mouse models for Rett syndrome.Frontiers in neurologyReview
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Many animal groups are organized hierarchically, which generates behavioral states that facilitate social interactions. Although generally stable, social status can change, underscoring the plasticity of underlying neural circuits. We examined competition among unfamiliar male mice and uncovered how the molecular and biophysical characteristics of a forebrain-thalamocortical circuit affect hierarchy. We identify the mediodorsal thalamus (MDT) as a hub receiving inputs from the orbitofrontal cortex and basal forebrain and projecting to the caudal anterior cingulate cortex (cACC) to regulate competitive performance. This circuit becomes potentiated or depressed in high- and low-rank males, respectively, in part through altered expression of the voltage-gated ion channel Trpm3 and synaptic plasticity. In high-rank mice, MDT projections drive inhibition of cACC pyramidal cells, promoting winning, in a pattern strikingly opposite to the dorsomedial prefrontal cortex, where winners display increased pyramidal cell activity. Our data suggest a model in which hierarchy modulation relies on coordinated remodeling of multiple forebrain-thalamocortical circuits.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.