ArticleCell reports. Medicine2025
Enhanced regenerative and developmental potential of embryonal and stem cell-derived platelets compared to adult platelets.
Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- The mitochondria-targeting compound PTC299 enhances megakaryocyte and platelet production.Stem cells translational medicine · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular features and multifaceted roles of platelets have been well characterized in adult mammals, but little is known about platelets at earlier developmental stages. In this study, we conduct transcriptomic and proteomic profiling of mouse embryonic platelets and find that, compared to adult platelets, they exhibit reduced classic immune-regulatory and procoagulant features but enhanced development-supporting traits. Notably, embryonic platelets interact more robustly with various cell types, including fibroblasts, and significantly accelerate refractory wound healing. Mechanistically, embryonic platelets promote fibroblast proliferation by releasing higher levels of IGF2. We also identify a CD59(a)
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Registered trials
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