ArticleEuropean heart journal. Cardiovascular Imaging2025
Cardiovascular magnetic resonance to differentiate veteran athlete's heart with cavity dilatation and mild dilated cardiomyopathy.
Article in European heart journal. Cardiovascular Imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Cardiopulmonary Exercise Testing in the Differential Diagnosis Between Athlete's Heart and Cardiac Pathology: Current Evidence and Diagnostic Challenges.Diagnostics (Basel, Switzerland) · 2026Review
- Review
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16 authors.
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Abstract
aimsThis study aimed to investigate the distribution of myocardial fibrosis and patterns of tissue characteristics on cardiovascular magnetic resonance (CMR) between athletes with left ventricular (LV) dilatation and mild dilated cardiomyopathy (DCM) patients. METHODS AND
resultsWe prospectively recruited male cyclists/triathletes aged ≥50 years who undertook ≥10 h/week of exercise for ≥15 years along with age-/sex-matched patients with non-ischaemic heart failure (HF). Participants underwent clinical assessment, 12-lead ECG, stress-perfusion CMR with fibrosis assessment, and parametric tissue mapping.Following CMR, included participants in both groups had left ventricular ejection fraction (LVEF) > 40% and left ventricular end-diastolic volume indexed to body surface area (LVEDVi) ≥ 110 mL/m2 without ischaemic heart disease or significant cardiac pathology on CMR likely to cause HF. Of 113 participants (64 athletes and 49 mild DCM patients), athletes with fibrosis demonstrated a greater prevalence of inferolateral fibrosis (87.5% vs. 50.0%, P = 0.002), whereas inferoseptal fibrosis was more common in mild DCM patients (45.8% vs. 9.4%, P = 0.002). Native T1 (1249.0 ± 38.1 vs. 1308.3 ± 47.1 ms, P < 0.001) and extracellular volume (ECV) (22.0 ± 2.1 vs. 25.9 ± 3.5%, P < 0.001) were lower in athletes. Athletes had greater right ventricular end-diastolic volume indexed to body surface area (RVEDVi) (121.0 ± 14.3 vs. 97.6 ± 25.2%, P < 0.001), myocardial perfusion reserve (MPR) (3.65 ± 1.30 vs. 2.76 ± 0.92, P < 0.001), and stress myocardial blood flow (MBF) (2.09 ± 0.70 vs. 1.62 ± 0.66, P < 0.001) than mild DCM patients. On receiver-operator curve analysis, native T1 [area under the curve (AUC) 0.89, P < 0.001], ECV (AUC 0.85, P < 0.001), RVEDVi (AUC 0.81, P < 0.001), and stress MBF (AUC 0.68, P = 0.002) were able to differentiate between groups.
conclusionSeptal fibrosis is rare amongst veteran athletes with LV dilation in contrast to mild DCM patients. Native T1, ECV, and RVEDVi can also discriminate between these overlapping phenotypes, which may be clinically useful.
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