ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2025
Adjuvanted Recombinant Zoster Vaccine is Effective Against Herpes Zoster Ophthalmicus, and is Associated With Lower Risk of Acute Myocardial Infarction and Stroke in Adults Aged ≥50 Years.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Neuro- and cardioprotective benefits of recombinant herpes zoster vaccination.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2026Article
- Recombinant shingles vaccination and the risk of cardiovascular events.Nature medicine · 2026Article
- Varicella zoster virus and the central nervous system.Nature reviews. Microbiology · 2026Review
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
backgroundHerpes zoster (HZ) and HZ ophthalmicus (HZO) are associated with an increased risk of cardiovascular complications, such as acute myocardial infarction (AMI) and stroke. We evaluated the association between recombinant zoster vaccine (RZV) and risk of HZO, hospitalized AMI, and hospitalized stroke in adults ≥50 years of age (YoA) at Kaiser Permanente Southern California.
methodsWe conducted a matched cohort analysis of adults ≥50 YoA who received 2 doses of RZV 4 weeks-6 months apart during 01 April 2018-31 December 2020 and were matched 1:4 to RZV-unvaccinated individuals on age, sex, race/ethnicity, and index date (date of second dose among vaccinated; unvaccinated match assigned same date). Follow-up started at index date and ended at receipt of zoster vaccine, termination of membership, death, or 31 December 2022, whichever came first. HZO was identified by natural language processing of clinical notes; hospitalized AMI and stroke were identified by ICD-10 codes. Stratified Cox proportional hazards regression was used to estimate adjusted hazard ratios (aHR) and 95% confidence intervals (CI).
resultsAmong 102 766 2-dose RZV-vaccinated and 411 064 unvaccinated adults, 59.0% were female, 57.1% non-Hispanic White, and median age was 68 years (range: 50-108). The aHRs (95% CI) of HZO, hospitalized AMI, and hospitalized stroke comparing RZV-vaccinated and unvaccinated individuals were 0.271 (95% CI: 0.222, 0.330), 0.720 (0.588-0.881), and 0.575 (0.533-0.619), respectively. The adjusted RZV effectiveness against HZO was 72.9% (67.0%-77.8%).
conclusionsAmong adults ≥50 YoA, 2 RZV doses were associated with a lower risk of HZO, AMI, and stroke.
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