Evidence map›Paper›PMID 40795266›Full record

ArticleJournal of medicinal chemistry2025

Engineering Peptide Modulators for T-Cell Migration by Structural Scaffold Matching.

Jasmin Gattringer, Simon Hasinger, Agnes Weidmann, Katarzyna Walczewska-Szewc, Kirtikumar B Jadhav, Tobias Zrzavy, Anja Steinmaurer, Paulien Baeten, Monika Perisic, Wilson Cochrane and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jasmin GattringerCenter for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
Simon HasingerCenter for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
Agnes WeidmannCenter for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.
Katarzyna Walczewska-SzewcInstitute of Physics, Faculty of Physics, Astronomy and Informatics, Nicolaus Copernicus University in Toruń, 87-100 Toruń, Poland.
Kirtikumar B JadhavFaculty of Chemistry, Institute of Biological Chemistry, University of Vienna, 1090 Vienna, Austria.
Tobias ZrzavyComprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, 1090 Vienna, Austria.
Anja SteinmaurerComprehensive Center for Clinical Neurosciences and Mental Health, Medical University of Vienna, 1090 Vienna, Austria.
Paulien BaetenDepartment of Immunology and Infection Biomedical Research Institute, Hasselt University, 3590 Diepenbeek, Belgium.
Monika PerisicFaculty of Chemistry, Institute of Biological Chemistry, University of Vienna, 1090 Vienna, Austria.ORCID 0009-0005-3413-1310
Wilson CochraneSchool of Biomedical Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia.
Markus MuttenthalerFaculty of Chemistry, Institute of Biological Chemistry, University of Vienna, 1090 Vienna, Austria.ORCID 0000-0003-1996-4646
Bieke BrouxDepartment of Immunology and Infection Biomedical Research Institute, Hasselt University, 3590 Diepenbeek, Belgium.
Dagmar GotthardtDepartment for Biological Sciences and Pathobiology, Pharmacology and Toxicology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria.
K Johan RosengrenSchool of Biomedical Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia.ORCID 0000-0002-5007-8434
Christian W GruberCenter for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0001-6060-7048
Roland HellingerCenter for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria.ORCID 0000-0002-8955-8793

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lymphocyte migration plays a crucial role in the progression of autoimmune and inflammatory diseases, and the inhibition of autoreactive immune cells is an attractive therapeutic strategy. Pepitem is an endogenous modulator of lymphocyte migration. In this study, we implemented a structural scaffold matching approach to engineer of stabilized pepitem-based probes. Prioritizing the native helix-loop-helix structure of pepitem, protein structure databases were mined to identify the structurally closest peptide scaffold. Leveraging this strategy, we developed VhTI-pep 2, inhibiting CD3

Indexed as

Cell MovementPeptidesT-LymphocytesHumansMultiple SclerosisProtein EngineeringStructure-Activity RelationshipPeptides

Identifiers

PMID40795266
PMCPMC12406255

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.