ReviewJournal of immunology (Baltimore, Md. : 1950)2025
Immunoglobulin GM (γ marker) allotypes and their role in immune response and disease susceptibility.
Review in Journal of immunology (Baltimore, Md. : 1950), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Human Antibody Isotypes, Subclasses, Allotypes and Fc Biology: Clinical Implications in Infectious Diseases, Autoimmunity, and Cancer.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Immunoglobulin GM (γ marker) allotypes expressed on IgG1 as potential genetic markers of response to immune checkpoint blockade therapy.Journal for immunotherapy of cancer · 2026Article
- Immunoglobulin allotypes andJournal of Alzheimer's disease : JAD · 2026Article
- Immunoglobulin γ allotypes influence the level of autoantibody responses to amyloid-β in patients with Alzheimer's disease.Human immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Immunoglobulin GM (γ marker) allotypes are encoded by 3 very closely linked and highly homologous immunoglobulin heavy chain G (IGHG) genes-IGHG1, IGHG2, and IGHG3-on chromosome 14q32. They are localized on the constant region of γ1, γ2, and γ3 chains. There are currently 18 serologically testable GM specificities. Linkage disequilibrium in the GM system within a racial/ethnic group is almost absolute and the determinants are transmitted as haplotypes. Major racial/ethnic groups are characterized by unique arrays of several GM haplotypes. In this article, I review the basic genetics of GM allotypes, their role in antibody responses to infectious pathogens and vaccines, their contribution to Fc-mediated effector functions, and their potential role in immunotherapy. Additionally, I discuss the association of GM allotypes with many autoimmune, infectious, and malignant diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.