Evidence map›Paper›PMID 40795058›Full record

ArticleThe ISME journal2025

Cyanuric acid in Paramecium secretions is an efficient quorum sensing inducer.

Xingyao Ye, Xiaojun Niu, Dongqing Zhang, Mengyu Lv, Ling Li, Qiang Liu, Deye Chen, Yu Lin, Zhiquan Yang, Yi Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The ISME journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xingyao YeSchool of Environment and Energy, South China University of Technology, Guangzhou 510006, PR China.
Xiaojun NiuSchool of Environment and Energy, South China University of Technology, Guangzhou 510006, PR China.
Dongqing ZhangSchool of Environmental Science and Engineering, Guangdong University of Petrochemical Technology, Maoming 525000, PR China.
Mengyu LvSchool of Environment and Energy, South China University of Technology, Guangzhou 510006, PR China.
Ling LiSchool of Environment and Energy, South China University of Technology, Guangzhou 510006, PR China.
Qiang LiuSchool of Environment and Energy, South China University of Technology, Guangzhou 510006, PR China.
Deye ChenChina Water Resources Pearl River Planning Surveying and Designing Co., Ltd., Guangzhou 510640, PR China.
Yu LinGuangzhou Urban Drainage Company Limited, Guangzhou 510006, PR China.
Zhiquan YangSchool of Environment and Energy, South China University of Technology, Guangzhou 510006, PR China.
Yi ZhangSchool of Environment and Energy, South China University of Technology, Guangzhou 510006, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quorum sensing is a process of bacterial chemical communication via extracellular signal molecules known as autoinducers, allowing synchronized collective behavior changes related to population density. However, the ecological significance of quorum sensing in multi-species communities, particularly coexisting with predators, remains unaddressed. In this study, we discovered that cyanuric acid (CA), a compound secreted by the widespread protozoan Paramecium, significantly influences the LuxR-type quorum sensing in Pseudomonas aeruginosa PAO1. Exogenous CA acts as a substitute for autoinducers known as N-acyl homoserine lactones in activating LasR/RhlR regulators that involve promiscuous ligand-receptor interactions, and exerts a specific restoring effect on the PAO1-ΔlasI/ΔrhlI mutant. Further, the inductive capabilities of CA were harnessed to expedite the start-up of the anammox process, substantially enhancing the aggregation and dynamics of the anammox consortium. Treating with 500 nM CA led to a 76.3% increase in anammox bacteria abundance compared to the control, resulting in exceptional nitrogen removal rates of 1.42 g N·L-1·d-1 within 54 days. This study unveils a mode of interspecies information transfer across trophic levels in aquatic organismal communities through CA-stimulated quorum sensing.

Indexed as

ParameciumPseudomonas aeruginosaQuorum SensingTriazinesBacterial ProteinsGene Expression Regulation, BacterialTrans-ActivatorsBacterial Proteinscyanuric acidTrans-ActivatorsTriazinesanammoxcyanuric acidParameciumquorum sensing

Identifiers

PMID40795058
PMCPMC12342508

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.