Observational studyThe western journal of emergency medicine2025
Pupillometry in the Emergency Department: A Tool for Predicting Patient Disposition.
Observational study in The western journal of emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Opposing Roles of OPN3 and OPN5 Affecting the Intrinsic Pupillary Light Reflex of the Mammalian Iris.Investigative ophthalmology & visual science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe ability to accurately assess and predict the disposition of comatose patients from within the emergency department (ED) remains a critical challenge. Traditional methods lack precision and consistency. Our goal was to evaluate the prognostic capability of the neurological pupil index (NPI) in predicting patient disposition from within the ED.
methodThis prospective observational study followed 50 comatose patients (Glasgow Coma Scale [GSC] score < 9) who were enrolled via convenience sampling and subsequently treated in the ED at a Level 1 trauma center and public safety-net hospital in San Francisco, CA. We calculated NPI scores and collected data on patient demographics, clinical characteristics, and outcomes. The NPI scores were categorized into three groups: 0 (very poor); 0.1-3.0 (poor to moderate); and 3.1-5.0 (good). We used ANOVA, the Pearson chi-squared test, Wilcoxon rank-sum test, and Fisher exact test to assess the association between NPI scores and discharge status. Results were reported as odds ratios with 95% confidence intervals, with a P-value < .05 considered statistically significant.
resultsThe median age of patients in this study was 58 years (IQR 42-74), and 66% were male. Higher NPI scores (five-point scale with 3.1-5.0 considered normal) were significantly associated with an increased likelihood of ED discharge (82%), , while lower NPI scores (0, nonreactive pupil) were predominantly associated with hospital admission (92%) (P < .001). Significant predictors of discharge status included patient age, GCS scores, and coma etiology.
conclusionThis study highlights the utility of the NPI in predicting patient disposition from within the ED. Higher NPI scores were strongly associated with an increased likelihood of ED discharge. These findings support the idea that NPI has the potential to enhance the accuracy of prognostic assessments, in comparison to subjective characterizations of pupil activity. Additional research with larger, multicenter cohorts are needed to confirm these results and establish standardized protocols for integration of NPI in ED workflow.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.