Evidence map›Paper›PMID 40794906›Full record

ArticleJournal of the National Cancer Institute2026

Childhood cancer data initiative: expanded access to tumor molecular profiling for children, adolescents, and young adults.

Joseph Flores-Toro, Subhashini Jagu, Malcolm Smith, John Shern, Douglas S Hawkins, Elaine R Mardis, Erin Rudzinski, Todd A Alonzo, Thalia Beeles, Nilsa Ramirez and 21 more

Abstract read
In one paragraph

Article in Journal of the National Cancer Institute, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Joseph Flores-ToroNational Cancer Institute, Bethesda, MD, United States.ORCID 0000-0001-7001-9071
Subhashini JaguNational Cancer Institute, Bethesda, MD, United States.ORCID 0000-0002-3888-2390
Malcolm SmithNational Cancer Institute, Bethesda, MD, United States.ORCID 0000-0001-9880-9876
John ShernNational Cancer Institute, Bethesda, MD, United States.ORCID 0000-0001-5579-7625
Douglas S HawkinsSeattle Children's Hospital, Seattle, WA, United States.ORCID 0000-0003-3602-1375
Elaine R MardisInstitute for Genomic Medicine, Nationwide Children's Hospital, Columbus, OH, United States.ORCID 0000-0002-5892-1553
Erin RudzinskiIndiana University, Indianapolis, IN, United States.ORCID 0000-0001-8020-3796
Todd A AlonzoUniversity of Southern California, Los Angeles, CA, United States.
Thalia BeelesChildren's Oncology Group, Monrovia, CA, United States.
Nilsa RamirezNationwide Children's Hospital, Columbus, OH, United States.ORCID 0000-0002-9945-9449
Diana L ThomasNationwide Children's Hospital, Columbus, OH, United States.ORCID 0000-0001-7004-2036
Catherine E CottrellNationwide Children's Hospital, Columbus, OH, United States.
Kareesma ParbhooNationwide Children's Hospital, Columbus, OH, United States.ORCID 0000-0002-4806-9571
Katherine A JanewayDana Farber Cancer Institute/Boston Children's Hospital, Boston, MA, United States.ORCID 0000-0001-6000-3594
Sarah LearySeattle Children's Hospital, Seattle, WA, United States.ORCID 0000-0003-0225-6184
Maryam FouladiNationwide Children's Hospital, Columbus, OH, United States.ORCID 0009-0005-3039-3313
Sapna OberoiChildren's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada.ORCID 0000-0002-6071-0042
Rajkumar VenkatramaniTexas Children's Hospital, Houston, TX, United States.ORCID 0000-0002-4785-106X
Meredith IrwinHospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-2452-5181
Theodore W LaetschChildren's Hospital of Philadelphia, Philadelphia, PA, United States.ORCID 0000-0002-8497-3138
Kenneth S ChenUniversity of Texas Southwestern, Dallas, TX, United States.ORCID 0000-0003-2304-4631
Kelly BaileyUniversity of Pittsburgh, Pittsburgh, PA, United States.ORCID 0000-0003-3925-3243
Jessica L DavisIndiana University, Indianapolis, IN, United States.ORCID 0000-0002-2725-1518
Mary Beth SullivanChildren's Oncology Group, Monrovia, CA, United States.ORCID 0009-0008-5310-634X
Emily BojaNational Cancer Institute, Bethesda, MD, United States.ORCID 0000-0002-0765-3827
Douglas LowyNational Cancer Institute, Bethesda, MD, United States.ORCID 0000-0003-0635-219X
Jaime M Guidry AuvilNational Cancer Institute, Bethesda, MD, United States.ORCID 0000-0002-5468-6592
Brigitte WidemanNational Cancer Institute, Bethesda, MD, United States.ORCID 0000-0002-9198-7175
Warren KibbeNational Cancer Institute, Bethesda, MD, United States.ORCID 0000-0001-5622-7659
James DoroshowNational Cancer Institute, Bethesda, MD, United States.ORCID 0000-0002-4463-1790
Gregory H ReamanNational Cancer Institute, Bethesda, MD, United States.ORCID 0000-0003-1803-1844

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
COG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8M
Pediatric brain tumors: Improving survival through integration of clinical molecular diagnostics and biologically targeted therapies into clinical trialsR50CA275857 · NCI · SEATTLE CHILDREN'S HOSPITAL · PI Sarah Elisabeth Sherr Leary · 2023 to 2026
$701k
Rare Tumor Clinical Research SpecialistR50CA305079 · NCI · CHILDREN'S HOSP OF PHILADELPHIA · PI Theodore Willis Laetsch · 2025 to 2026
$395k
Central upon the Official Date of PublicationChildhood Cancer Data InitiativeIntramural NIH HHS Z99 CA999999NCI NIH HHS R50 CA275857NCI NIH HHS R50 CA305079NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899NIH HHS
6 · The paper itself

Abstract

The Molecular Characterization Initiative (MCI), a key effort of the National Cancer Institute's Childhood Cancer Data Initiative (CCDI), was launched in 2022 in collaboration with the Children's Oncology Group (COG) to bring comprehensive genomic and molecular profiling to children, adolescents, and young adults diagnosed with cancer. The MCI provides paired tumor and germline molecular testing, with results returned to clinicians to inform care. Deidentified data are made available to the research community through the CCDI Data Ecosystem to facilitate the discovery of new treatment strategies. This commentary outlines the MCI's development, key accomplishments to date, and its role in laying the foundation for standardized clinical diagnostics in pediatric oncology.

Indexed as

NeoplasmsAdolescentChildGene Expression ProfilingHumansNational Cancer Institute (U.S.)United StatesYoung Adult

Identifiers

PMID40794906
PMCPMC12360469

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.