Evidence map›Paper›PMID 40794821›Full record

ArticleJournal of travel medicine2025

A framework to assess the risk of yellow fever emergence.

Charlotte Perlant, Raphaëlle Klitting, Vittoria Colizza, Katy A M Gaythorpe, Gaëlle Gabiane, Xavier de Lamballerie, Anna B Failloux, Simon Cauchemez, Paolo Bosetti

Abstract read
In one paragraph

Article in Journal of travel medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Charlotte PerlantMathematical Modelling of Infectious Diseases Unit, Institut Pasteur, Université de Paris Cité INSERM U1332,CNRS UMR2000, 28 rue du Dr Roux, Paris, 75015, France.ORCID 0009-0009-9644-5402
Raphaëlle KlittingNational Reference Center for Arboviruses, Inserm-IRBA, 27 boulevard Jean Moulin, Marseille, 13385 Cedex 5, France.ORCID 0000-0002-7777-0308
Vittoria ColizzaPierre Louis Institute of Epidemiology and Public Health, Sorbonne Université, INSERM, 27 rue de Chaligny, Paris, 75012, France.ORCID 0000-0002-2113-2374
Katy A M GaythorpeMedical Research Council Centre for Global Infectious Disease Analysis, Imperial College London, 90 Wood Lane, London, W12 0BZ, UK.
Gaëlle GabianeDepartment of Virology, Arboviruses and Insect Vectors, Institut Pasteur, 26 rue du Dr Roux, Paris, 75015, France.
Xavier de LamballerieNational Reference Center for Arboviruses, Inserm-IRBA, 27 boulevard Jean Moulin, Marseille, 13385 Cedex 5, France.ORCID 0000-0001-7895-2720
Anna B FaillouxDepartment of Virology, Arboviruses and Insect Vectors, Institut Pasteur, 26 rue du Dr Roux, Paris, 75015, France.ORCID 0000-0001-6890-0820
Simon CauchemezMathematical Modelling of Infectious Diseases Unit, Institut Pasteur, Université de Paris Cité INSERM U1332,CNRS UMR2000, 28 rue du Dr Roux, Paris, 75015, France.ORCID 0000-0001-9186-4549
Paolo BosettiMathematical Modelling of Infectious Diseases Unit, Institut Pasteur, Université de Paris Cité INSERM U1332,CNRS UMR2000, 28 rue du Dr Roux, Paris, 75015, France.

Funding

BMGF INV-034281 and INV-009125/OPP1157270EU Horizon 2020 H2020-874850European Commission under the EU4Health 101102733Gates Foundation INV-009125Gavi 226727_Z_22_ZHorizon Europe grant ESCAPE 101095619INCEPTION PIA/ANR16-CONV-0005Laboratoire d'Excellence Integrative Biology of Emerging Infectious Diseases ANR-10-LABX-62-IBEID
6 · The paper itself

Abstract

backgroundYellow fever (YF) is a viral hemorrhagic fever transmitted by Aedes aegypti mosquitoes. Symptoms range from mild fever to severe complications such as jaundice and haemorrhages, which can be fatal. Martinique, a French island in the Caribbean, has remained YF-free since 1908. However, the reintroduction of A. aegypti in the 1970s, the limited scope of mandatory vaccination-currently required only for international travellers to endemic areas-and increased connectivity to YF-endemic regions heighten its vulnerability. To inform local preparedness activities, we assessed the risk of YF emergence, defined as introduction and establishment, by looking at vector competence of local native species of A. aegypti in Martinique.

methodsWe developed a framework to evaluate YF emergence risk, integrating multiple contributing factors and taking Martinique as a case study. We used reported cases from 2015 to 2022 to estimate the predicted force of infection in endemic countries and map genotype presence in source countries. In addition, we analyzed flight traffic patterns from 2019 to 2022 and computed genotype-specific transmission efficiency by local mosquito populations.

resultsBefore 2020, Brazil represented the greatest YF introduction risk due to high passenger volumes. However, the moderate transmissibility of the South America II YF virus strain in Martinique's mosquito populations partially mitigated this risk. The COVID-19 pandemic disrupted global travel, temporarily shifting the risk landscape towards African countries such as Ivory Coast and Cameroon, where the West African strain exhibits higher transmissibility. However, this risk remained limited by the low number of travellers from these regions.

conclusionsThere are growing concerns about the risk of YF introduction and emergence in non-endemic territories like Martinique. Climate change, mosquito adaptability (e.g. egg resistance to desiccation, winter diapause) and intensified global travel drive this risk. This integrative risk assessment framework supports YF emergence prevention and could be applied to other at-risk territories.

Indexed as

AedesCommunicable Diseases, EmergingTravelYellow FeverAnimalsBrazilHumansMartiniqueMosquito VectorsRisk AssessmentYellow fever virusforce of infectiongeneticRisk assessmentvector competenceyellow fever

Identifiers

PMID40794821
PMCPMC12491664

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.