Evidence map›Paper›PMID 40794764›Full record

ArticleEndocrinology2025

Nonavian Reptile Reproduction Functions With a Reduced Gonadotropin System.

Maya S Kummrow, Jose V Roig-Genovés, Ignacio Giménez, Athanasia C Tzika, Marcus Clauss, Stephan C F Neuhauss, Jean-Michel Hatt, Matthias Gesemann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maya S KummrowClinic for Zoo Animals, Exotic Pets and Wildlife, Department for Small Animals, University of Zurich, Zurich 8057, Switzerland.ORCID 0000-0002-5343-1336
Jose V Roig-GenovésRara Avis Biotec, Valencia 46002, Spain.ORCID 0000-0001-8288-859X
Ignacio GiménezRara Avis Biotec, Valencia 46002, Spain.ORCID 0000-0003-4357-6555
Athanasia C TzikaDepartment of Genetics and Evolution, University of Geneva, Geneva 1205, Switzerland.ORCID 0000-0002-0831-5221
Marcus ClaussClinic for Zoo Animals, Exotic Pets and Wildlife, Department for Small Animals, University of Zurich, Zurich 8057, Switzerland.ORCID 0000-0003-3841-6207
Stephan C F NeuhaussDepartment of Molecular Life Sciences, University of Zurich, Zurich 8057, Switzerland.ORCID 0000-0002-9615-480X
Jean-Michel HattClinic for Zoo Animals, Exotic Pets and Wildlife, Department for Small Animals, University of Zurich, Zurich 8057, Switzerland.ORCID 0000-0002-7043-7430
Matthias GesemannDepartment of Molecular Life Sciences, University of Zurich, Zurich 8057, Switzerland.ORCID 0000-0001-7635-1235

Funding

Foundation for Research in Science and the Humanities at the University of Zurich STWF-20-010Wolfermann Nägeli Stiftung
6 · The paper itself

Abstract

Vertebrate reproduction is controlled by 2 pituitary gonadotropin hormones (GtHs), FSH and LH, binding to gonadotropin hormone receptors (GtHRs) in gonadal tissues. All gnathostome vertebrates have been confirmed to possess at least 1 receptor for each GtH [LH receptor (LHR) and FSH receptor (FSHR)], except for species of the reptilian (nonavian sauropsidan) orders, such as lepidosauria, testudines, and crocodylia, which showed inexplicable reactions to heterologous amphibian, avian, and mammalian GtHs in early endocrinological studies. This study investigated the number and function of reptilian GtHRs. Genomic and transcriptomic analyses of selected tetrapod species now strongly suggest the inactivation of the LHR in all nonavian sauropsidans. This gene inactivation likely occurred independently in 3 branches of the sauropdisan clade, sparing only the avian class. Bioassays served to investigate the binding specificity of squamate, chelonian, crocodilian, avian, and mammalian GtHRs with their homologous and heterologous GtHs. The FSHR of a squamate lizard proved completely promiscuous to both its homologous GtHs, while the chelonian FSHR responded slightly stronger to the homologous LH than FSH, and the crocodylian FSHR was only stimulated by the homologous LH but not FSH. We therefore propose a modified paradigm with a neuroendocrine control of nonavian reptilian reproduction by a single GtHR and either 1 GtH in crocodylians or 2 GtHs in chelonians and squamate reptiles. Finally, we discuss hypotheses of tightly regulated temporal and spatial expression of the remaining FSHR in different gonadal somatic cells and temperature-dependent functions of the single nonavian reptilian GtHR.

Indexed as

GonadotropinsReproductionReptilesAnimalsFollicle Stimulating HormoneLuteinizing HormonePhylogenyReceptors, FSHReceptors, LHFollicle Stimulating HormoneGonadotropinsLuteinizing HormoneReceptors, FSHReceptors, LHendocrinological bioassaygonadotropin hormone receptorligand-receptor coevolutionnonavian sauropsidareductive evolutionreproduction

Identifiers

PMID40794764
PMCPMC12360902

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.