ArticleThe Journal of infectious diseases2026
Hyperendemicity of Rift Valley Fever in Southwestern Uganda Associated With the Rapidly Evolving Lineage C Viruses.
Article in The Journal of infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Opportunities and challenges for countermeasures against Rift Valley fever virus: A quintessential One Health pathogen.PLoS neglected tropical diseases · 2026Review
- Evolutionary dynamics and molecular adaptation of Rift Valley fever virus across human and non-human outbreaks in Africa.BMC genomics · 2026Article
- Understanding the Rift Valley fever exposure risk: A comparative perspective from a multi-country study in East and Central Africa, 2021-24.PLoS neglected tropical diseases · 2026Article
- A Cross-Sectional Study of Rift Valley Fever Exposure in Humans and Livestock in Southwestern Uganda Using a One Health Approach: Evidence of Elevated Seroprevalence Outside Recognized Outbreak Periods.Pathogens (Basel, Switzerland) · 2026Article
- Interepidemic Rift Valley fever in East Africa: the recent risk landscape and projected impacts of global change.Proceedings. Biological sciences · 2026Article
- Patterns of antibiotic use for acute febrile illness in resource-limited settings: a multicenter study in DR Congo, Kenya and Uganda.Frontiers in public health · 2026Article
- Exploring community-based reporting of livestock abortions for rift valley fever and brucellosis surveillance in Uganda: a pilot study.Scientific reports · 2025Article
- Rift Valley Fever Virus Transmission During an Unreported Outbreak Among People and Livestock in South-Central Tanzania.Viruses · 2025Article
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Abstract
backgroundRecent Rift Valley fever (RVF) epidemiology in the eastern Africa region is characterized by widening geographic range and increasing frequency of small disease clusters. Here we conducted studies in the southwestern (SW) Uganda region that has since 2016 reported increasing RVF activities.
methodsA 22-month long hospital-based study in 3 districts of SW Uganda targeting patients with acute febrile illness or unexplained bleeding was followed by a cross-sectional population-based human-animal survey. We then estimated RVF virus (RVFV) force of infection and yearly cases using age-structured seroprevalence data and conducted genomic phylodynamic modelling of RVFV isolates.
resultsOverall RVF prevalence was 10.5% (205/1968) among febrile or hemorrhagic cases, including 5% (100/1968) with acute (PCR or IgM positive) infection, averaging 5 cases per month. Community-based seroprevalence of 11.8% (88/743) among humans and 14.6% (347/2383) in livestock was observed. Expected yearly human RVF cases were 314-2111 per 1369 km2 in SW Uganda, up to 3-fold higher than the 0-711 yearly cases in comparable regions of Kenya and Tanzania. Viral genomic studies identified RVFV lineage C, subclade C.2.2 as the circulating strain in SW Uganda since 2019. Lineage C strain has undergone recent rapid evolution and clonal expansion resulting in 4 subclades, C.1.1, C.1.2, C.2.1, and C.2.2, that are adept at establishing endemicity in new territories.
conclusionsWe demonstrate an atypical RVF hyperendemic region in SW Uganda characterized by sustained human clinical RVF cases, unusually high population prevalence, and high number of expected yearly human cases, associated in part with emergence of new RVFV sublineages.
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