ArticlePloS one2025
Unveiling the drivers of geographic atrophy progression in eyes with reticular pseudodrusen.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
purposeTo evaluate the progression rate of geographic atrophy (GA) and identify factors associated with GA expansion in eyes with reticular pseudodrusen (RPD) using fundus autofluorescence (FAF) photography.
methodsA total of 28 eyes from 28 patients diagnosed with GA and RPD, who completed a 3-year follow-up, was included. The eyes underwent thorough examination with color fundus photography, FAF and near infrared (NIR) imaging, and spectral domain optical coherence tomography (SD OCT). The areas of atrophic lesions were quantified using FAF images at years 1, 2, and 3 employing a semi-automated software (Region Finder).
resultsThe rate of increase in mean GA area in eyes with RPD was calculated to be 0.39 ± 0.21 mm per year over the 3-year period. The annual progression rate measured over three years showed a statistically significant increase each year. Univariate analysis revealed that subfoveal choroidal thickness (SFCT) and RPD distribution were independently associated with GA progression (P ≤ 0.037). In multivariate analysis, thin SFCT was the only significant factor linked to an increased rate of GA growth. The progression from extrafoveal GA to foveal GA was solely associated with the initial square root GA area.
conclusionThese results offer valuable insights for the development of interventional strategies aimed at mitigating GA enlargement in this specific subgroup of patients.
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