Evidence map›Paper›PMID 40794378›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2025

Impact of myocardial revascularization surgery on the plasma metabolome.

Felipe Fernandes Pires Barbosa, Marco Antonio Coral Pinto, Álex Ap Rosini Silva, Luisa Oliveira Messias, Vanessa Bertolucci, Pedro Paulo Menezes Scariot, Lucas Miguel de Carvalho, José Geraldo Cardoso Junior, Andréia de Melo Porcari, Leonardo Henrique Dalcheco Messias

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Article in Metabolomics : Official journal of the Metabolomic Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Felipe Fernandes Pires BarbosaResearch Group on Technology Applied to Exercise Physiology-GTAFE, Health Sciences Postgraduate Program, São Francisco University, Francisco de Assis av, 218, 12900000, Bragança Paulista, 12916-900, SP, Brazil.
Marco Antonio Coral PintoResearch Group on Technology Applied to Exercise Physiology-GTAFE, Health Sciences Postgraduate Program, São Francisco University, Francisco de Assis av, 218, 12900000, Bragança Paulista, 12916-900, SP, Brazil.
Álex Ap Rosini SilvaMS4Life Laboratory of Mass Spectrometry, Health Sciences Postgraduate Program, São Francisco University, Bragança Paulista, 12916- 900, SP, Brazil.
Luisa Oliveira MessiasResearch Group on Technology Applied to Exercise Physiology-GTAFE, Health Sciences Postgraduate Program, São Francisco University, Francisco de Assis av, 218, 12900000, Bragança Paulista, 12916-900, SP, Brazil.
Vanessa BertolucciResearch Group on Technology Applied to Exercise Physiology-GTAFE, Health Sciences Postgraduate Program, São Francisco University, Francisco de Assis av, 218, 12900000, Bragança Paulista, 12916-900, SP, Brazil.
Pedro Paulo Menezes ScariotResearch Group on Technology Applied to Exercise Physiology-GTAFE, Health Sciences Postgraduate Program, São Francisco University, Francisco de Assis av, 218, 12900000, Bragança Paulista, 12916-900, SP, Brazil.
Lucas Miguel de CarvalhoLaboratory of Systems Biology and Omics in Health Science- LaBSOmiCS, Health Sciences Postgraduate Program, São Francisco University, Bragança Paulista, 12916-900, SP, Brazil.
José Geraldo Cardoso JuniorResearch Group on Technology Applied to Exercise Physiology-GTAFE, Health Sciences Postgraduate Program, São Francisco University, Francisco de Assis av, 218, 12900000, Bragança Paulista, 12916-900, SP, Brazil.
Andréia de Melo PorcariMS4Life Laboratory of Mass Spectrometry, Health Sciences Postgraduate Program, São Francisco University, Bragança Paulista, 12916- 900, SP, Brazil.
Leonardo Henrique Dalcheco MessiasResearch Group on Technology Applied to Exercise Physiology-GTAFE, Health Sciences Postgraduate Program, São Francisco University, Francisco de Assis av, 218, 12900000, Bragança Paulista, 12916-900, SP, Brazil. leonardo.messias@usf.edu.br.ORCID http://orcid.org/0000-0002-8324-8866

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 408680/2021-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.504805/2020-00
6 · The paper itself

Abstract

introductionMyocardial revascularization (MR) is recommended in acute myocardial infarction. Understanding the physiological disturbances caused by MR may be pertinent for future therapeutic strategies in the postoperative period.

objectivesThis study aims to analyze the MR impact on plasma metabolites and investigate potential correlations between them with routinely measured biochemical and clinical parameters in MR, and with the cardiopulmonary bypass time (CPB).

methodsTwenty-five patients had plasma samples collected before and after MR for metabolomic analysis, performed by liquid chromatography coupled with high-resolution mass spectrometry.

resultsOne hundred eleven ions showed statistically significant differences due to MR and thirteen were identified. Only Pregnenolone Sulfate had its abundance in plasma decreased due to MR. Hydrocortisone succinate, Cortisone, and Corticosterone increased in response to the glucocorticoids administered during surgery. LysoPS 16:1, LysoPC 14:0, Phenylvaleric acid, 13-Hydroxyoctadecadienoic acid, N-Linoleoyl Glutamine, and N-Myristoyl Methionine, along with the significant increase in the white blood cell count are associated with inflammation processes, possibly caused by MR. Furthermore, Pregnenolone sulfate, Pentosidine, Phenylvaleric acid, and N-Myristoyl Methionine were correlated with biochemical/clinical parameters and CPB.

conclusionThese results open new horizons in the interpretation of physiological disturbances caused by MR, as well as provide support for future studies. The scientific community is invited to build upon the outcomes obtained to confirm the associations suggested in this study, advancing the realm of metabolomics and MR.

Indexed as

MetabolomeMyocardial RevascularizationAgedCardiopulmonary BypassChromatography, LiquidFemaleHumansMaleMass SpectrometryMetabolomicsMiddle AgedMyocardial InfarctionCardiologyIntensive care unitIschemic cardiomyopathyMass-spectrometryMetabolomics

Identifiers

PMID40794378

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.