SynthesisInflammopharmacology2025
A systematic review of the role of interleukin inhibitors in lichen planus: therapeutic and paradoxical effects.
Synthesis in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Upadacitinib is effective in treating psoriasis combined with lichen planus: a case report.Frontiers in medicine · 2026Article
- Mechanisms Underlying Lichen Planus in Association with Biologic Therapy.Journal of inflammation research · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLichen planus (LP) is a group of chronic inflammatory disorders of the skin, mucous membranes, scalp, and nails that mainly affect the middle-aged population. Inflammatory modifiers, including interferon-α (IFN-α), IFN-γ, tumor necrosis factor-alpha (TNF-α), as well as various interleukins (ILs), such as IL-4, IL-5, IL-6, IL-8, IL-9, IL-10, IL-12, IL-17, IL-18, IL-21, IL-22, and IL-23 has also been suggested to contribute in the LP pathogenesis. We aim to systematically evaluate the effect of IL inhibitors on treating and triggering LP disease.
methodsA systematic search was conducted up to January 30th, 2025, in PubMed/Medline, Web of Science, and Ovid-Embase, and clinical studies with available English full-text were included.
resultsThe search recorded 196 relevant studies, with 42 articles eligible for this study. IL-inhibitors, including dupilumab, secukinumab, anakinra, tildrakizumab, guselkumab, ustekinumab, ixekizumab, risankizumab, and brodalumab were associated with clinical improvement in various types of LP. In contrast, in some cases with a coexistent autoimmune disease, such as psoriasis and atopic dermatitis, secukinumab, dupilumab, risankizumab, ustekinumab, and ixekizumab administration resulted in LP development.
conclusionIL inhibitors demonstrate both treatment and paradoxical effects on LP. Further research is needed to elucidate the impact of these agents on the pathophysiology of LP.
Indexed as
Identifiers
40794374What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.