ArticleJournal of cardiovascular translational research2025
The Impact of Obesity on Pressure-Volume Relationship in Ambulatory Heart Failure.
Article in Journal of cardiovascular translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Heart failure with a preserved ejection fraction: synergy between cardiac and extracardiac mechanisms and effects of novel therapies.Heart failure reviews · 2026Review
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Assessment of volume status is essential in heart failure (HF) management, yet the relationship between cardiac filling pressures and true intravascular volume remains unclear, especially in patients with obesity. We analyzed 262 ambulatory HF patients who underwent blood volume analysis (BVA) and same-day right heart catheterization. Patients were stratified by BMI into non-obese (n = 104), obese (n = 121), and morbidly obese (n = 37). Cardiac filling pressures showed modest correlations with directly measured total blood volume (TBV); RAP correlated with TBV %deviation (r = 0.36-0.58), while PCWP correlations were weaker (r = 0.19-0.36) and non-significant in morbidly obese patients. Concordance between pressure and volume was highest in non-obese patients (RAP/TBV 79.8%, PCWP/TBV 69.2%) and lower in obese (66.1%, 55.4%) and morbidly obese individuals (64.9%, 67.6%). Approximately one-third or more of obese patients exhibited discordant pressure-volume profiles. These findings suggest that in obesity, cardiac filling pressures may not reliably reflect volume status.
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Registered trials
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