ArticleGenes & genomics2025
Regulation of intracellular proliferation of Salmonella typhimurium by CD63.
Article in Genes & genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Ubiquilin 1 Inhibits intracellular proliferation of Salmonella enterica serovar Typhimurium through Xenophagy.Genes & genomics · 2026Article
- Crosstalk Between Allergic Inflammation and Autophagy.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
backgroundAutophagy is an intracellular degradation process involving the lysosomal breakdown of unnecessary or abnormal cellular components. Targets of autophagy include pathogens, altered organelles, and protein aggregates, which are sequestered within double-membrane-limited vesicles known as autophagosomes. A variety of lysosomal membrane proteins play essential roles in numerous cellular processes, including lysosomal acidification, metabolite transport, and interaction with other membrane systems. Cluster of differentiation 63 (CD63), a member of the transmembrane 4 superfamily, is present on the cell surface and in intracellular membrane compartments, such as endosomal and lysosomal membranes. This protein is also associated with several diseases, including Hermansky-Pudlak syndrome and immunoglobulin E-mediated allergies. However, its role in the autophagy pathway and intracellular bacterial proliferation remains poorly understood.
objectiveThis study aimed to investigate changes in CD63 expression in response to Salmonella infection and to analyze the effects of these changes on Salmonella proliferation.
methodsChanges in CD63 expression were examined following Salmonella infection using cellular models. Expression regulation was assessed for dependence on nuclear factor kappa B signaling. Colocalization of CD63 was evaluated with green fluorescent protein-tagged Salmonella and the lysosomal marker LysoTracker. Intracellular Salmonella titers were measured and correlated with CD63 expression levels to determine impacts on bacterial survival.
resultsCD63 expression increased in response to Salmonella infection in a nuclear factor kappa B-dependent manner. CD63 colocalized with green fluorescent protein-tagged Salmonella and the lysosomal marker LysoTracker. The titer of intracellular Salmonella was inversely correlated with CD63 expression, suggesting that higher CD63 levels reduce bacterial survival.
conclusionCD63 contributes to the regulation of intracellular Salmonella survival through the autophagy pathway, specifically xenophagy (autophagy targeting pathogens). This is the first report documenting the inhibition of Salmonella proliferation via induction of CD63 expression and Xenophagy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.