Evidence map›Paper›PMID 40794248›Full record

ArticleTranslational stroke research2025

Exploring the Association Between Early PaCO

Mingfeng Cao, Camila S Contreras-Rojas, Qihong Wang, Yaman B Ahmed, Jessica Briscoe, Carlos A Pardo, Hannah Rando, Jin Kook Kang, Glenn Whitman, Steve Keller and 2 more

Abstract read
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In one paragraph

Article in Translational stroke research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mingfeng CaoDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 1800 Orleans Street, Baltimore, MD, 21287, USA.
Camila S Contreras-RojasUniversity of Chicago Pritzker School of Medicine, Chicago, IL, USA.
Qihong WangPulmonary & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Yaman B AhmedDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 1800 Orleans Street, Baltimore, MD, 21287, USA.
Jessica BriscoeDivision of Cardiac Surgery, Department of Surgery, Heart and Vascular Institute, Cardiovascular Surgical Intensive Care, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Carlos A PardoDepartments of Neurology and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Hannah RandoDivision of Cardiac Surgery, Department of Surgery, Heart and Vascular Institute, Cardiovascular Surgical Intensive Care, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jin Kook KangDivision of Cardiac Surgery, Department of Surgery, Heart and Vascular Institute, Cardiovascular Surgical Intensive Care, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Glenn WhitmanDivision of Cardiac Surgery, Department of Surgery, Heart and Vascular Institute, Cardiovascular Surgical Intensive Care, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Steve KellerPulmonary & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Tito PorrasDivision of Cardiac Surgery, Department of Surgery, Heart and Vascular Institute, Cardiovascular Surgical Intensive Care, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Sung-Min ChoDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 1800 Orleans Street, Baltimore, MD, 21287, USA. csungmi1@jhmi.edu.

Funding

Johns Hopkins University Magic That Matters foundation grantNIH HHS 1K23HL157610; 1R21NS135045
6 · The paper itself

Abstract

backgroundPrior clinical research demonstrated that rapid reduction in arterial carbon dioxide (PaCO

methodsIn this prospective preclinical experimental study, six female pigs (mean weight: 50.75 ± 1.89 kg) were subjected to 15 min of ventricular fibrillation and were then supported by ECMO. The return of spontaneous circulation (ROSC) was attempted in animals at 20 min post-ECMO initiation. Arterial blood gas (ABG) was sampled at specific time points, while arterial blood pressure (ABP) and intracranial pressure (ICP) were continuously monitored. Sweep gas flow was set relative to each animal's ECMO flow rate: 100% in the control group, 200% in the rapid correction group, and 25% in the slow correction group. PRx was computed as the Pearson correlation coefficient between 10-s average mean arterial pressure (MAP) and ICP values using 1-min windows updated every 30 s. Experimental phases were defined for data analysis, including baseline, fibrillation, ECMO I (0-10 min after ECMO initiation), ECMO II (10-20 min), and POST-R (post-ROSC, 20-30 min). Linear mixed-effects models were used to assess group-wise differences in ΔPRx over time. Histopathological analysis was performed to quantify neuronal injury across cortical and subcortical regions. Brain tissues were harvested and histologically analyzed for neuronal injury ischemia vulnerable regions: the midbrain, cerebellum, striatum in the basal ganglia, temporal cortex, hypothalamus, and hippocampus.

resultsIn the rapid group, PaCO

conclusionIn this experimental ECPR model, faster early PaCO

Indexed as

Carbon DioxideCardiopulmonary ResuscitationCerebrovascular CirculationExtracorporeal Membrane OxygenationHomeostasisAnimalsBlood Gas AnalysisDisease Models, AnimalFemaleHeart ArrestIntracranial PressureSwineCarbon DioxideCVARECMOECPRHistologyPaCO2

Identifiers

PMID40794248

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.