Evidence map›Paper›PMID 40794198›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2025

Targeting mutated KRAS by HLA-A*02:01 restricted anti-KRAS TCR-mimic CAR and bispecific T cell engager.

Saber Ebrahimi, Benedikt J Lohnes, Shamsul A Khan, Matthias Peipp, Ernesto Bockamp, Christian Klein, Hinrich Abken, Catherine Wölfel, Matthias Theobald, Udo F Hartwig

Abstract read
In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. A KRASMolecular therapy. Oncology · 2025
    Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Saber EbrahimiIIIrd. Department of Medicine - Hematology & Medical Oncology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
Benedikt J LohnesIIIrd. Department of Medicine - Hematology & Medical Oncology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
Shamsul A KhanIIIrd. Department of Medicine - Hematology & Medical Oncology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
Matthias PeippDivision of Stem Cell Transplantation and Immunotherapy, Department of Internal Medicine II, University Hospital Schleswig Holstein, Campus Christian-Albrechts-University, Kiel, Germany.
Ernesto BockampInstitute of Translational Immunology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
Christian KleinRoche Innovation Center Zuerich, Roche Pharma Research & Early Development, Schlieren, Switzerland.
Hinrich AbkenLeibniz Institute for Immunotherapy, Regensburg, Germany.
Catherine WölfelIIIrd. Department of Medicine - Hematology & Medical Oncology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
Matthias TheobaldIIIrd. Department of Medicine - Hematology & Medical Oncology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany.
Udo F HartwigIIIrd. Department of Medicine - Hematology & Medical Oncology, University Medical Center, Johannes Gutenberg-University, Mainz, Germany. uhartwig@uni-mainz.de.ORCID 0000-0002-6714-6923

Funding

Horizon 2020 Framework Programme 01KU2107Horizon 2020 Framework Programme 2021 - 2024
6 · The paper itself

Abstract

Mutations in the KRAS proto-oncogene, particularly at codon 12, are among the most frequent genetic alterations in various cancers, and KRAS

Indexed as

HLA-A2 AntigenMutationProto-Oncogene Proteins p21(ras)Receptors, Antigen, T-CellReceptors, Chimeric AntigenT-LymphocytesAntigens, NeoplasmCell Line, TumorHumansImmunotherapy, AdoptiveKiller Cells, NaturalProto-Oncogene MasAntigens, NeoplasmHLA-A*02:01 antigenHLA-A2 AntigenKRAS protein, humanMAS1 protein, humanProto-Oncogene MasProto-Oncogene Proteins p21(ras)Receptors, Antigen, T-CellReceptors, Chimeric AntigenChimeric antigen receptorImmunotherapyKRAS neoepitopesT cell therapyTCR-mimic bispecific antibodyTCR-mimic CAR

Identifiers

PMID40794198
PMCPMC12449438

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.