ArticleEuropean journal of applied physiology2026
Urinary N-terminal titin fragment concentration as a non-invasive biomarker of exercise-induced muscle damage in males and females.
Article in European journal of applied physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo examine the effects of muscle-damaging exercise on urinary N-terminal fragments of titin (UTF) in males and females, and its association with markers of exercise-induced muscle damage.
methods27 males (n = 16) and females (n = 11) (height: 1.74 ± 0.10 m; body mass: 72.2 ± 11.4 kg; age: 22 ± 3 years) performed 200 eccentric contractions of the knee extensor on an isokinetic dynamometer. Urine and serum samples were collected pre-, post- and 48 h post-exercise to quantify UTF and creatine kinase (CK). Additionally, knee extensor maximal voluntary isometric force (MVIF), voluntary activation (VA), time to peak twitch (TTP), evoked maximal rate of force development (RFD
resultsUTF (2.3 ± 1.8 to 3.3 ± 3.4 nmol/mg/dL) and CK (9.7 ± 4.8 to 14.5 ± 8.7 units/L) concentrations were elevated 48 h after exercise (p < 0.01). DOMS was greater at all post-exercise time points vs. pre-exercise (p < 0.01). MVIF, evoked RFD
conclusionUTF was similarly increased post- and 48 h post-exercise in males and females and was moderately to strongly correlated to CK and some markers of neuromuscular function, but not DOMS.
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