Evidence map›Paper›PMID 40794175›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

Comparing outcomes with different dialysis modalities in children with kidney failure: home hemodialysis versus in-center hemodiafiltration or conventional hemodialysis.

Charlotte Ahlmann, Iona Madden, Andreas Busjahn, Olga Panagiotopoulou, Karolis Azukaitis, Sevcan A Bakkaloglu, Ayşe Ağbaş, Ali Anarat, Varvara Askiti, Aysun K Bayazit and 24 more

Abstract readComparative StudyMulticenter Study
PubMed Publisher
In one paragraph

Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Is home best when it comes to pediatric hemodialysis?Pediatric nephrology (Berlin, Germany) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Charlotte AhlmannUniversity College London Great Ormond Street Hospital and Institute of Child Health, London, WC1N 3JH, UK.
Iona MaddenUniversity College London Great Ormond Street Hospital and Institute of Child Health, London, WC1N 3JH, UK. Madden.Iona@gmail.com.ORCID http://orcid.org/0000-0001-8679-0960
Andreas BusjahnHealthTwiSt GmbH, Berlin, Germany.
Olga PanagiotopoulouUniversity College London Great Ormond Street Hospital and Institute of Child Health, London, WC1N 3JH, UK.
Karolis AzukaitisPediatric Nephrology Unit, Clinic of Pediatrics, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Sevcan A BakkalogluPediatric Nephrology Unit, Gazi University Hospital, Ankara, Türkiye.
Ayşe AğbaşPediatric Nephrology Unit, Cerrahpasa School of Medicine, Istanbul, Türkiye.
Ali AnaratPediatric Nephrology Unit, Cukurova University, Adana, Türkiye.
Varvara AskitiPediatric Nephrology Unit, Panagiotis & Aglaia Kyriakou Children's Hospital, Athens, Greece.
Aysun K BayazitPediatric Nephrology Unit, Cukurova University, Adana, Türkiye.
Ipek Kaplan BulutPediatric Nephrology Unit, Faculty of Medicine, Ege University, Izmir, Türkiye.
Nur CanpolatPediatric Nephrology Unit, Cerrahpasa School of Medicine, Istanbul, Türkiye.
Dagmara Borzych-DuzalkaDepartment of Pediatrics, Nephrology and Hypertension, Medical University of Gdansk, Gdansk, Poland.
Ali DuzovaDivision of Pediatric Nephrology, Hacettepe University, Ankara, Türkiye.
Sandra HabbigDepartment of Pediatrics, Faculty of Medicine, University Hospital Cologne and University of Cologne, Cologne, Germany.
Saoussen KridPediatric Nephrology Unit, Hôpital Necker-Enfants Malades, Paris, France.
Christoph LichtPediatric Nephrology Unit, The Hospital for Sick Children, Toronto, ON, Canada.
Mieczyslaw LitwinDepartment of Nephrology, Kidney Transplantation and Hypertension, Children's Memorial Health Institute, Warsaw, Poland.
Lukasz ObryckiDepartment of Nephrology, Kidney Transplantation and Hypertension, Children's Memorial Health Institute, Warsaw, Poland.
Fabio PaglialongaPediatric Nephrology, Dialysis and Transplant Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Bruno RanchinPediatric Nephrology Unit, Hôpital Femme Mère Enfant, Université de Lyon, Hospices Civils de LyonBron, France.
Charlotte SamailleDepartment of Pediatric Nephrology, CHU Lille Pole Enfant, Lille, France.
Mohan ShenoyPediatric Nephrology Unit, Royal Manchester Children's Hospital, Manchester, UK.
Manish D SinhaPediatric Nephrology Unit, Kings College London Evelina London Children's Hospital, London, UK.
Brankica SpasojevicPediatric Nephrology Unit, University Children's Hospital, Belgrade, Serbia.
Lynsey StronachUniversity College London Great Ormond Street Hospital and Institute of Child Health, London, WC1N 3JH, UK.
Enrico VidalPediatric Nephrology Unit, University-Hospital of Padua, Padua, Italy.
Alev YilmazPediatric Nephrology Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Türkiye.
Michel FischbachNephrology Dialysis Transplantation Children's Unit, University Hospital Hautepierre, Strasbourg, France.
Franz SchaeferPediatric Nephrology Division, Department of Pediatrics I, University of Heidelberg, Heidelberg, Germany.
Claus Peter SchmittPediatric Nephrology Division, Department of Pediatrics I, University of Heidelberg, Heidelberg, Germany.
Jun OhPediatric Nephrology Unit, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Daljit HothiUniversity College London Great Ormond Street Hospital and Institute of Child Health, London, WC1N 3JH, UK.
Rukshana ShroffUniversity College London Great Ormond Street Hospital and Institute of Child Health, London, WC1N 3JH, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHome hemodialysis (HHD) and hemodiafiltration (HDF) have independently shown superior cardiovascular outcomes compared with conventional hemodialysis (HD) in adults, but pediatric data are scarce. We compared outcomes on HHD, HDF and HD therapies in children.

methodsSingle-center data from HHD patients over 13 years were compared with the multicenter prospective "3H - HDF, Heart and Height" study. Systolic blood pressure [SBP] standard deviation score [SDS], left ventricular mass index [LVMI], height-SDS, biochemical markers, dialysis-related symptoms and medication burden were compared within the HHD cohort and between the three dialysis modalities at baseline and 12 months.

resultsAmong 38 HHD patients with complete follow-up, there were no improvements in SBP-SDS, LVMI or height-SDS over 12 months. Serum phosphate levels decreased (median difference -0.15 mmol/L [95% CI -0.5 to -0.1]; p = 0.002) and hemoglobin increased (+ 1.1 g/dL [95% CI 0.3 to 2.0]; p = 0.01). Comparing 38 HHD patients to 55 HDF and 78 HD patients, SBP-SDS, LVMI, and height-SDS were comparable between HHD and HDF at 12 months. LVMI was lower in HHD compared with HD (-11.8 g/m

conclusionsIn pediatric patients, HHD and HDF showed comparable outcomes for cardiovascular burden, growth, and dialysis-related symptoms, and both demonstrated superior clinical outcomes compared with conventional HD.

Indexed as

HemodiafiltrationHemodialysis, HomeKidney Failure, ChronicRenal DialysisAdolescentBlood PressureChildChild, PreschoolFemaleFollow-Up StudiesHumansMaleProspective StudiesTreatment OutcomeCardiovascular diseaseChildrenConventional hemodialysis (HD)GrowthHemodiafiltration (HDF)Home hemodialysis (HHD)

Identifiers

PMID40794175

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.