Evidence map›Paper›PMID 40794101›Full record

ArticleCell biochemistry and function2025

The Role of Lactate in Mitochondrial Metabolism of DOX-Induced Senescent AC16 Cells.

Rosamaria Militello, Simone Luti, Tania Gamberi, Manuela Leri, Alice Santi, Matteo Becatti, Alessio Pellegrino, Pietro Amedeo Modesti, Alessandra Modesti

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell biochemistry and function, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rosamaria MilitelloDepartment of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
Simone LutiDepartment of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
Tania GamberiDepartment of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
Manuela LeriDepartment of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
Alice SantiDepartment of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
Matteo BecattiDepartment of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.
Alessio PellegrinoDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Pietro Amedeo ModestiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy.
Alessandra ModestiDepartment of Biomedical, Experimental and Clinical Sciences "Mario Serio", University of Florence, Florence, Italy.ORCID https://orcid.org/0000-0002-1290-2285

Funding

This study was supported by grants from University of Florence (Grant: Simonelutiricaten23 and AlessandraModestiricaten24 - MIUR Progetti finanziati dal Ministero dell'Istruzione, dell'Università e della Ricerca PNRR_ECO_THE_SPOKE_2).
6 · The paper itself

Abstract

Senescent cells accumulate with age in organ and tissue causing the decline of functionality and various pathological conditions including cardiovascular disease. Regular exercise induces continuous exposure to lactate that contribute to adaptive process through mitochondrial biogenesis and improve of metabolic process. Lactate accumulation during exercise also appears to be associated with exercise-induced mitochondrial adaptation. Improvement of mitochondria function through lactate exposure could be a tool to prevent cardiomyocytes senescence and cardiac aging. The aim of the following article is to investigate the role of lactate in Doxorubicin-induced senescent AC16 human cardiomyocytes cell mitochondrial metabolism. We assessed the metabolic behaviour in senescent cardiomyocytes after chronic lactate exposure and provided a discussion of the effect of this metabolite in regulating mitochondrial physiology during cardiac aging.

Indexed as

Cellular SenescenceDoxorubicinLactic AcidMitochondriaMyocytes, CardiacCell LineHumansDoxorubicinLactic AcidDOX‐induced senescent AC16 cellsmetabolomicsmitochondrial dysfunctionproteomics

Identifiers

PMID40794101
PMCPMC12341654

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.