Evidence map›Paper›PMID 40793865›Full record

ArticleAging cell2025

Differential Effects of Liver Regeneration on Aging-Related Changes in Gene Expression and Metabolic Function.

Ryo Murayama, Kenichi Horisawa, Shizuka Miura, Sumiaki Taniguchi, Jinghao Shu, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Kousei Ishigami, Atsushi Suzuki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ryo MurayamaDivision of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Kenichi HorisawaDivision of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Shizuka MiuraDivision of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Sumiaki TaniguchiDivision of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Jinghao ShuDivision of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Masatomo TakahashiDivision of Metabolomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Yoshihiro IzumiDivision of Metabolomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Takeshi BambaDivision of Metabolomics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.
Kousei IshigamiDepartment of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Atsushi SuzukiDivision of Organogenesis and Regeneration, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.ORCID 0000-0002-6347-5498

Funding

Japan Agency for Medical Research and Development JP24bm1123005Japan Agency for Medical Research and Development JP24fk0210116Japan Agency for Medical Research and Development JP25fk0210170Japan Society for the Promotion of Science JP18H05102Japan Society for the Promotion of Science JP19H01177Japan Society for the Promotion of Science JP19H05267Japan Society for the Promotion of Science JP20H05040Japan Society for the Promotion of Science JP21K18039Japan Society for the Promotion of Science JP22H00592Japan Society for the Promotion of Science JP22H04698Japan Society for the Promotion of Science JP22H05634Japan Society for the Promotion of Science JP23K11851Japan Society for the Promotion of Science JP23K17199Japan Society for the Promotion of Science JP23K18579Japan Society for the Promotion of Science JP25H00445Japan Society for the Promotion of Science JP25K03454Medical Research Center Initiative for High Depth OmicsMEXT Promotion of Development of a Joint Usage/Research System Project: Coalition of Universities for Research Excellence Program JPMXP1323015486MEXT Promotion of Development of a Joint Usage/Research System Project: Cooperative Research Project ProgramNaito FoundationShinnihon Foundation of Advanced Medical Treatment ResearchTakeda Science FoundationUehara Memorial Foundation
6 · The paper itself

Abstract

Aging causes significant changes in gene expression and metabolic function of cells in various organs. Although it is known that liver regeneration is delayed by aging, the effects of aging on changes in gene expression and metabolic functions in liver regeneration need further investigation. In this study, we comprehensively analyzed changes in gene expression and metabolic function by liver regeneration in young and old mice to examine the effects of aging on these changes. During the process of liver regeneration, the gene expression profiles of hepatocytes from young and old mice changed significantly in a stepwise manner while each remained close together. After the completion of liver regeneration, the genes with aging-specific expression patterns in old mouse hepatocytes changed to expression levels close to those in young mouse hepatocytes. In contrast to the results of these transcriptome analyses, the aging-specific changes in metabolic state detected in old mouse livers were found to be largely maintained after the completion of liver regeneration. These results demonstrated that the gene expression state in the liver of old mice is flexibly altered by liver regeneration, whereas their metabolic state is robust. This finding helps to elucidate the relationship between aging and liver regeneration and to determine the basis of the increased incidence of liver disease with aging.

Indexed as

AgingLiver RegenerationAnimalsGene Expression ProfilingGene Expression RegulationHepatocytesLiverMaleMiceMice, Inbred C57BLTranscriptomeaginggene expressionlivermetabolismregeneration

Identifiers

PMID40793865
PMCPMC12507397

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.