Evidence map›Paper›PMID 40793791›Full record

ArticleJournal of virology2025

DDX54 drives ALKBH5-mediated demethylation of selected transcripts to suppress interferon antiviral response.

Hao-Yu Sun, Xiu-Ying Gong, Zi-Ling Qu, Li-Li An, Wen-Hao Guo, Hong-Yu Luan, Meng-Yao Wu, Ji-Cheng Yu, Cheng Dan, Yi-Bing Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hao-Yu SunKey Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.ORCID 0000-0003-2814-2863
Xiu-Ying GongKey Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Zi-Ling QuKey Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Li-Li AnKey Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Wen-Hao GuoKey Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Hong-Yu LuanKey Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Meng-Yao WuKey Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Ji-Cheng YuKey Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Cheng DanKey Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Yi-Bing ZhangKey Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.ORCID 0000-0001-7647-9335

Funding

Chinese Academy of Sciences XDB0730100
6 · The paper itself

Abstract

DEAD-box (DDX) proteins are currently reported to shape host innate immunity by regulation of N

Indexed as

AlkB Homolog 5, RNA DemethylaseDEAD-box RNA HelicasesInterferon Type IAdenosineDemethylationHEK293 CellsHost-Pathogen InteractionsHumansImmunity, InnateInterferonsRNA, MessengerSignal TransductionVesiculovirusVirus ReplicationAdenosineALKBH5 protein, humanAlkB Homolog 5, RNA DemethylaseDEAD-box RNA HelicasesInterferonsInterferon Type IN-methyladenosineRNA, MessengerALKBH5DEAD-box helicase 54demethylation activityinterferon responsesubstrate selectivity

Identifiers

PMID40793791
PMCPMC12456001

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.