Evidence map›Paper›PMID 40793781›Full record

ArticlemBio2025

Hi-C untangles the temporal dynamics of the children's gut resistome and mobilome, highlighting the role of transposable elements.

Sara G Cifuentes, Jay Graham, Gabriel Trueba, Paúl A Cárdenas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sara G CifuentesInstituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito USFQ, Quito, Pichincha, Ecuador.
Jay GrahamBerkeley School of Public Health, University of California, Berkeley, California, USA.
Gabriel TruebaInstituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito USFQ, Quito, Pichincha, Ecuador.ORCID 0000-0003-2617-9021
Paúl A CárdenasInstituto de Microbiología, Colegio de Ciencias Biológicas y Ambientales, Universidad San Francisco de Quito USFQ, Quito, Pichincha, Ecuador.ORCID 0000-0001-9626-4489

Funding

Research Mentoring and Building Capacity of underrepresented Minority Research Scientists in India.D43TW010540 · FIC · YALE UNIVERSITY · PI MICHELE BARRY, Eva Harris · 2017 to 2026
$15.5M
Antimicrobial Resistance Transmission Associated with Small-Scale Food-Animal Production in Peri-Urban Communities of Quito, EcuadorR01AI135118 · NIAID · UNIVERSITY OF CALIFORNIA BERKELEY · PI GRAHAM, JAY PAUL · 2018 to 2021
$2.0M
FIC NIH HHS D43 TW010540NIAID NIH HHS R01 AI135118
6 · The paper itself

Abstract

Many metagenomic studies lack the ability to measure the temporal dynamics of the intestinal resistome (the collection of antibiotic resistance genes [ARGs]) and mobilome (the collection of all mobile genetic elements that enable their transfer) and link the genetic features to specific species in the gut. We applied Hi-C sequencing and shotgun metagenomics to study fecal matter from children (

Indexed as

BacteriaDNA Transposable ElementsDrug Resistance, BacterialGastrointestinal MicrobiomeAnti-Bacterial AgentsChildChild, PreschoolEcuadorFecesFemaleGene Transfer, HorizontalHumansMaleMetagenomicsPlasmidsAnti-Bacterial AgentsDNA Transposable Elementsantibiotic resistancegut microbiotaHi-C metagenomicsmobile genetic elementstransposable elements

Identifiers

PMID40793781
PMCPMC12421864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.